Incidence, trends and ethnic differences of oropharyngeal, anal and cervical cancers

Singapore, 1968-2012

Jennifer O. Lam, Wei Yen Lim, Khuan Yew Chow, Gypsyamber D'Souza

Research output: Contribution to journalArticle

Abstract

In recent decades, several Western countries have reported an increase in oropharyngeal and anal cancers caused by human papillomavirus (HPV). Trends in HPV-associated cancers in Asia have not been as well described. We describe the epidemiology of potentially HPV-related cancers reported to the Singapore Cancer Registry from 1968-2012. Analysis included 998 oropharyngeal squamous cell carcinoma (OPSCC), 183 anal squamous cell carcinoma (ASCC) and 8,019 invasive cervical cancer (ICC) cases. Additionally, 368 anal non-squamous cell carcinoma (ANSCC) and 2,018 non-oropharyngeal head and neck carcinoma (non-OP HNC) cases were included as comparators. Age-standardized incidence rates (ASR) were determined by gender and ethnicity (Chinese, Malay and Indian). Joinpoint regression was used to evaluate annual percentage change (APC) in incidence. OPSCC incidence increased in both genders (men 1993-2012, APC = 1.9%, p

Original languageEnglish (US)
Article numbere0146185
JournalPLoS One
Volume10
Issue number12
DOIs
StatePublished - Dec 1 2015

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Anus Neoplasms
Oropharyngeal Neoplasms
ethnic differences
uterine cervical neoplasms
Singapore
Uterine Cervical Neoplasms
Papillomaviridae
Squamous Cell Carcinoma
squamous cell carcinoma
incidence
neoplasms
Incidence
carcinoma
Carcinoma
Neoplasms
Epidemiology
Registries
gender
Neck
nationalities and ethnic groups

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Incidence, trends and ethnic differences of oropharyngeal, anal and cervical cancers : Singapore, 1968-2012. / Lam, Jennifer O.; Lim, Wei Yen; Chow, Khuan Yew; D'Souza, Gypsyamber.

In: PLoS One, Vol. 10, No. 12, e0146185, 01.12.2015.

Research output: Contribution to journalArticle

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