Incidence of tuberculosis and the importance of treatment of latent tuberculosis infection in a Spanish prison population

V. M. Sánchez, J. M. Guerra, J. A. Cayla, J. C. Rodriguez, M. D. Blanco, M. Alcoba

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To establish the incidence of tuberculosis (TB) in a prison population and its link with latent tuberculosis infection treatment (LTIT). METHODS: From 1991 to 1999 a TB programme was run in a Spanish prison. A cohort study was conducted to know TB incidence and the associated variables. RESULTS: Of 1050 people studied, 10% were co-infected by the human immunodeficiency virus (HIV) and Mycobacterium tuberculosis. Twenty-three cases of TB were detected, an incidence rate of 6.39 per 1000 person-years of follow-up. Multivariate analysis showed HIV-infected patients (RR 4.07, 95%CI 2.61-6.35), and those infected by M. tuberculosis who did not undergo LTIT (RR 10.15, 95%CI 0.90-50.59) to be at greater risk of developing TB. In TST reactors, those co-infected with HIV (RR 10.15, 95%CI 3.80-27.07) and those who had not undergone LTIT (RR 8.53, 95%CI 1.12-64.86) were shown to be at the greatest risk of developing TB. CONCLUSIONS: The observed incidence of TB is much higher in prisons than in the community at large. HIV-M. tuberculosis co-infection appears as the main risk factor for developing TB, while LTIT significantly reduces incidence.

Original languageEnglish (US)
Pages (from-to)926-932
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume5
Issue number10
StatePublished - Oct 29 2001

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Keywords

  • HIV
  • Latent tuberculosis infection treatment
  • Prison
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Sánchez, V. M., Guerra, J. M., Cayla, J. A., Rodriguez, J. C., Blanco, M. D., & Alcoba, M. (2001). Incidence of tuberculosis and the importance of treatment of latent tuberculosis infection in a Spanish prison population. International Journal of Tuberculosis and Lung Disease, 5(10), 926-932.