Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa

Cari Van Schalkwyk, Ebrahim Variava, Adrienne E. Shapiro, Modiehi Rakgokong, Katlego Masonoke, Limakatso Lebina, Alex Welte, Neil Martinson

Research output: Contribution to journalArticle

Abstract

Objective: To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB. Design: A prospective cohort study in the Matlosana sub-district of North West Province, South Africa. Methods: Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined. Results: For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py). Conclusions: In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.

Original languageEnglish (US)
Article numbere95372
JournalPLoS One
Volume9
Issue number4
DOIs
StatePublished - Apr 23 2014

Fingerprint

South Africa
households
HIV
incidence
Incidence
Testing
counseling
HIV infections
cohort studies
Namibia
HIV Infections
Disease Progression
Counseling
Cohort Studies
Prospective Studies
testing

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Van Schalkwyk, C., Variava, E., Shapiro, A. E., Rakgokong, M., Masonoke, K., Lebina, L., ... Martinson, N. (2014). Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. PLoS One, 9(4), [e95372]. https://doi.org/10.1371/journal.pone.0095372

Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. / Van Schalkwyk, Cari; Variava, Ebrahim; Shapiro, Adrienne E.; Rakgokong, Modiehi; Masonoke, Katlego; Lebina, Limakatso; Welte, Alex; Martinson, Neil.

In: PLoS One, Vol. 9, No. 4, e95372, 23.04.2014.

Research output: Contribution to journalArticle

Van Schalkwyk, C, Variava, E, Shapiro, AE, Rakgokong, M, Masonoke, K, Lebina, L, Welte, A & Martinson, N 2014, 'Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa', PLoS One, vol. 9, no. 4, e95372. https://doi.org/10.1371/journal.pone.0095372
Van Schalkwyk C, Variava E, Shapiro AE, Rakgokong M, Masonoke K, Lebina L et al. Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. PLoS One. 2014 Apr 23;9(4). e95372. https://doi.org/10.1371/journal.pone.0095372
Van Schalkwyk, Cari ; Variava, Ebrahim ; Shapiro, Adrienne E. ; Rakgokong, Modiehi ; Masonoke, Katlego ; Lebina, Limakatso ; Welte, Alex ; Martinson, Neil. / Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. In: PLoS One. 2014 ; Vol. 9, No. 4.
@article{4c6c7690d16e422da22314524db2edfc,
title = "Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa",
abstract = "Objective: To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB. Design: A prospective cohort study in the Matlosana sub-district of North West Province, South Africa. Methods: Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined. Results: For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95{\%} CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95{\%} CI 2.9-9.0/100py) and 0.7/100py (95{\%} CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95{\%} CI 1.3-8.4/100py). Conclusions: In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.",
author = "{Van Schalkwyk}, Cari and Ebrahim Variava and Shapiro, {Adrienne E.} and Modiehi Rakgokong and Katlego Masonoke and Limakatso Lebina and Alex Welte and Neil Martinson",
year = "2014",
month = "4",
day = "23",
doi = "10.1371/journal.pone.0095372",
language = "English (US)",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa

AU - Van Schalkwyk, Cari

AU - Variava, Ebrahim

AU - Shapiro, Adrienne E.

AU - Rakgokong, Modiehi

AU - Masonoke, Katlego

AU - Lebina, Limakatso

AU - Welte, Alex

AU - Martinson, Neil

PY - 2014/4/23

Y1 - 2014/4/23

N2 - Objective: To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB. Design: A prospective cohort study in the Matlosana sub-district of North West Province, South Africa. Methods: Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined. Results: For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py). Conclusions: In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.

AB - Objective: To report the incidence rates of TB and HIV in household contacts of index patients diagnosed with TB. Design: A prospective cohort study in the Matlosana sub-district of North West Province, South Africa. Methods: Contacts of index TB patients received TB and HIV testing after counseling at their first household visit and were then followed up a year later, in 2010. TB or HIV diagnoses that occurred during the period were determined. Results: For 2,377 household contacts, the overall observed TB incidence rate was 1.3 per 100 person years (95% CI 0.9-1.9/100py) and TB incidence for individuals who were HIV-infected and HIV seronegative at baseline was 5.4/100py (95% CI 2.9-9.0/100py) and 0.7/100py (95% CI 0.3-1.4/100py), respectively. The overall HIV incidence rate was 2.2/100py (95% CI 1.3-8.4/100py). Conclusions: In the year following a household case finding visit when household contacts were tested for TB and HIV, the incidence rate of both active TB and HIV infection was found to be extremely high. Clearly, implementing proven strategies to prevent HIV acquisition and preventing TB transmission and progression to disease remains a priority in settings such as South Africa.

UR - http://www.scopus.com/inward/record.url?scp=84899762717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899762717&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0095372

DO - 10.1371/journal.pone.0095372

M3 - Article

C2 - 24759741

AN - SCOPUS:84899762717

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e95372

ER -