Incidence of restless legs syndrome and its correlates

Pooja Budhiraja, Rohit Budhiraja, James L. Goodwin, Richard P. Allen, Anne B. Newman, Brian B. Koo, Stuart F. Quan

Research output: Contribution to journalArticle

Abstract

Background: Restless legs syndrome (RLS) is a common sensorimotor disorder whose incidence is not known. The aim of the study was to determine the incidence and correlates of RLS in a population-based sample. Methods: We obtained data from the Tucson Cohort of the Sleep Heart Health Study, a prospective multicenter study. This cohort included 535 participants aged ≥ 40 years, who answered questions regarding RLS on the 2002 and 2006 sleep surveys. For this study, RLS was defi ned as the presence of all 4 International RLS Study Group criteria, with symptoms occurring ≥ 5 days/month and associated with at least moderate distress. Results: Mean age of the predominantly Caucasian (90.8%) participants on the 2002 survey was 59.8 ± 9.7 years; 52.2% were women. RLS prevalence was 4.1% in 2002 and 7.7% in 2006. The yearly incidence of RLS was 1.7% (6.6% over 4 years). Multivariate analyses demonstrated that estrogen use (OR = 2.5, 95% CI: 1.17-5.10) and self-reported obstructive lung disease (OR = 2.8, 95% CI: 1.37-5.83) were independent risk factors predicting incident RLS. Incident RLS was associated with higher prevalence of insomnia (26.5% vs. 7.6%, p = 0.001), increased sleepiness (38.2% vs. 22%, p = 0.036); and higher sleeping pill use in 2006 (23.5% vs. 9.7%, p = 0.019). Conclusion: The incidence of RLS in this population sample was 1.7% per year. Use of estrogen and history of obstructive lung disease were associated with a signifi cantly higher incidence of RLS. RLS, in turn, was associated with insomnia and increased sleepiness.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalJournal of Clinical Sleep Medicine
Volume8
Issue number2
DOIs
StatePublished - Apr 15 2012

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Keywords

  • COPD
  • Estrogen
  • Incidence
  • Obstructive airway disease
  • Restless legs syndrome

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Cite this

Budhiraja, P., Budhiraja, R., Goodwin, J. L., Allen, R. P., Newman, A. B., Koo, B. B., & Quan, S. F. (2012). Incidence of restless legs syndrome and its correlates. Journal of Clinical Sleep Medicine, 8(2), 119-124. https://doi.org/10.5664/jcsm.1756