TY - JOUR
T1 - Incidence of respiratory virus-associated pneumonia in urban poor young children of dhaka, bangladesh, 2009-2011
AU - Homaira, Nusrat
AU - Luby, Stephen P.
AU - Petri, William A.
AU - Vainionpaa, Raija
AU - Rahman, Mustafizur
AU - Hossain, Kamal
AU - Snider, Cynthia B.
AU - Rahman, Mahmudur
AU - Alamgir, A. S.M.
AU - Zesmin, Farzina
AU - Alam, Masud
AU - Gurley, Emily S.
AU - Zaman, Rashid Uz
AU - Azim, Tasnim
AU - Erdman, Dean D.
AU - Fry, Alicia M.
AU - Bresee, Joseph
AU - Widdowson, Marc Alain
AU - Haque, Rashidul
AU - Azziz-Baumgartner, Eduardo
PY - 2012/2/22
Y1 - 2012/2/22
N2 - Background: Pneumonia is the leading cause of childhood death in Bangladesh. We conducted a longitudinal study to estimate the incidence of virus-associated pneumonia in children aged &2 years in a low-income urban community in Dhaka, Bangladesh. Methods: We followed a cohort of children for two years. We collected nasal washes when children presented with respiratory symptoms. Study physicians diagnosed children with cough and age-specific tachypnea and positive lung findings as pneumonia case-patients. We tested respiratory samples for respiratory syncytial virus (RSV), rhinoviruses, human metapneumovirus (HMPV), influenza viruses, human parainfluenza viruses (HPIV 1, 2, 3), and adenoviruses using real-time reverse transcription polymerase chain reaction assays. Results: Between April 2009-March 2011, we followed 515 children for 730 child-years. We identified a total of 378 pneumonia episodes, 77% of the episodes were associated with a respiratory viral pathogen. The overall incidence of pneumonia associated with a respiratory virus infection was 40/100 child-years. The annual incidence of pneumonia/100 child-years associated with a specific respiratory virus in children aged &2years was 12.5 for RSV, 6 for rhinoviruses, 6 for HMPV, 4 for influenza viruses, 3 for HPIV and 2 for adenoviruses. Conclusion: Young children in Dhaka are at high risk of childhood pneumonia and the majority of these episodes are associated with viral pathogens. Developing effective low-cost strategies for prevention are a high priority.
AB - Background: Pneumonia is the leading cause of childhood death in Bangladesh. We conducted a longitudinal study to estimate the incidence of virus-associated pneumonia in children aged &2 years in a low-income urban community in Dhaka, Bangladesh. Methods: We followed a cohort of children for two years. We collected nasal washes when children presented with respiratory symptoms. Study physicians diagnosed children with cough and age-specific tachypnea and positive lung findings as pneumonia case-patients. We tested respiratory samples for respiratory syncytial virus (RSV), rhinoviruses, human metapneumovirus (HMPV), influenza viruses, human parainfluenza viruses (HPIV 1, 2, 3), and adenoviruses using real-time reverse transcription polymerase chain reaction assays. Results: Between April 2009-March 2011, we followed 515 children for 730 child-years. We identified a total of 378 pneumonia episodes, 77% of the episodes were associated with a respiratory viral pathogen. The overall incidence of pneumonia associated with a respiratory virus infection was 40/100 child-years. The annual incidence of pneumonia/100 child-years associated with a specific respiratory virus in children aged &2years was 12.5 for RSV, 6 for rhinoviruses, 6 for HMPV, 4 for influenza viruses, 3 for HPIV and 2 for adenoviruses. Conclusion: Young children in Dhaka are at high risk of childhood pneumonia and the majority of these episodes are associated with viral pathogens. Developing effective low-cost strategies for prevention are a high priority.
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U2 - 10.1371/journal.pone.0032056
DO - 10.1371/journal.pone.0032056
M3 - Article
C2 - 22384139
AN - SCOPUS:84857480303
SN - 1932-6203
VL - 7
JO - PloS one
JF - PloS one
IS - 2
M1 - e32056
ER -