Incidence of ESKD and mortality among children with congenital heart disease after cardiac surgery

Chirag Parikh, Jason H. Greenberg, Eric McArthur, Heather Thiessen Philbrook, Allen D Everett, Ron Wald, Michael Zappitelli, Rahul Chanchlani, Amit X. Garg

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Abstract

Background and objectives Survival after surgical repair for congenital heart disease has markedly improved; however, there are limited data on long-term ESKD and mortality during childhood. Design, setting, participants, & measurements We conducted an observational, population-based cohort study of children who had their first surgery for congenital heart disease within 10 years of birth. The study was conducted in Ontario, Canada, where residents have universal access to health care services. Each child who underwent surgical repair was matched to ten children from the general population who were similar in age, sex, index date, rurality, and neighborhood income. Primary outcomes of all-cause mortality and ESKD were reported until March 2015. Results We followed 3600 children with congenital heart disease for a median of 5.9 (interquartile range, 2.9–9.0) years after their surgical repair. Median age at first surgery was 150 (interquartile range, 40–252) days and 22% were low birth weight (,2500 g). During follow-up, 140 (4%) children who had surgery for congenital heart disease died and 52 (1%) reached ESKD. The cumulative incidence of death and ESKD at 1, 5, and 10 years was higher in children with surgical repair of congenital heart disease (death: 3%, 4%, and 5%, respectively; ESKD: 1%, 2%, and 2%, respectively) compared with the matched control population without any congenital heart disease (death: 0.06%, 0.10%, and 0.13%, respectively; ESKD: 0.00%, 0.02%, and 0.02%, respectively). The risk of ESKD and death increased with severity of congenital heart disease, with the highest risk in children with hypoplastic left heart syndrome and increased in children who had surgical repair of congenital heart disease compared with those without surgical repair. Conclusions The risk of mortality and ESKD is high in children who undergo surgical repair for congenital heart disease compared to the general population.

Original languageEnglish (US)
Pages (from-to)1450-1457
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 7 2019

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ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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