Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration

D. D. Von Hoff; J. S. Penta; L. J. Helman; M. Slavik

Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration

D. D. Von Hoff, J. S. Penta, L. J. Helman, M. Slavik

School of Medicine

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.

Original language	English (US)
Pages (from-to)	745-748
Number of pages	4
Journal	Cancer treatment reports
Volume	61
Issue number	4
State	Published - Dec 1 1977

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration",

abstract = "A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.",

author = "{Von Hoff}, {D. D.} and Penta, {J. S.} and Helman, {L. J.} and M. Slavik",

year = "1977",

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T1 - Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration

AU - Von Hoff, D. D.

AU - Penta, J. S.

AU - Helman, L. J.

AU - Slavik, M.

PY - 1977/12/1

Y1 - 1977/12/1

N2 - A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.

AB - A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.

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M3 - Article

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AN - SCOPUS:0017713675

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JF - Cancer treatment reports

IS - 4

ER -

Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration

Abstract

ASJC Scopus subject areas

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