Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration

D. D. Von Hoff, J. S. Penta, L. J. Helman, M. Slavik

Research output: Contribution to journalArticle

Abstract

A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalCancer treatment reports
Volume61
Issue number4
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Von Hoff, D. D., Penta, J. S., Helman, L. J., & Slavik, M. (1977). Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration. Cancer treatment reports, 61(4), 745-748.