Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration

D. D. Von Hoff, J. S. Penta, Lee J. Helman, M. Slavik

Research output: Contribution to journalArticle

Abstract

A review of 498 patients treated with high-dose methotrexate (MTX) with citrovorum factor rescue revealed 29 drug-related deaths. Until the important factors in those deaths are identified, the use of high-dose MTX should be limited to institutions that possess the necessary supportive facilities and the ability to measure serum levels of the drug.

Original languageEnglish (US)
Pages (from-to)745-748
Number of pages4
JournalCancer Treatment Reports
Volume61
Issue number4
StatePublished - 1977
Externally publishedYes

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Leucovorin
Methotrexate
Incidence
Pharmaceutical Preparations
Serum

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Von Hoff, D. D., Penta, J. S., Helman, L. J., & Slavik, M. (1977). Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration. Cancer Treatment Reports, 61(4), 745-748.

Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration. / Von Hoff, D. D.; Penta, J. S.; Helman, Lee J.; Slavik, M.

In: Cancer Treatment Reports, Vol. 61, No. 4, 1977, p. 745-748.

Research output: Contribution to journalArticle

Von Hoff, DD, Penta, JS, Helman, LJ & Slavik, M 1977, 'Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration', Cancer Treatment Reports, vol. 61, no. 4, pp. 745-748.
Von Hoff, D. D. ; Penta, J. S. ; Helman, Lee J. ; Slavik, M. / Incidence of drug related deaths secondary to high dose methotrexate and citrovorum factor administration. In: Cancer Treatment Reports. 1977 ; Vol. 61, No. 4. pp. 745-748.
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