Incidence and risk factors for hepatocellular carcinoma after solid organ transplantation

Christopher Hoffmann, Aruna K. Subramanian, Andrew M Cameron, Eric A. Engels

Research output: Contribution to journalArticle

Abstract

Background.: Solid organ transplant recipients commonly are infected with hepatitis viruses, are immunosuppressed, and have other potential hepatocellular carcinoma (HCC) risk factors. Methods.: We studied de novo HCC incidence arising after transplant using U.S. registry data (223,660 recipients, 1987-2005). We used proportional hazards regression to identify HCC risk factors and calculated standardized incidence ratios (SIRs) to compare HCC risk with that in the general population. Results.: Based on 74 cases reported by transplant centers to the registry, HCC incidence was 6.5 per 100,000 person-years among kidney, heart, and lung (non-liver) recipients and 25 per 100,000 person-years among liver recipients. Hepatocellular carcinoma incidence among non-liver recipients was independently associated with hepatitis B surface antigenemia (hazard ratio [HR] 9.7, 95% confidence interval [CI] 2.8-33), hepatitis C virus (HCV) infection (HR 6.9, 95% CI 2.5-19), and diabetes mellitus (HR 2.8, 95% CI 1.2-6.6). Among liver recipients, HCC incidence was associated with advancing age (P

Original languageEnglish (US)
Pages (from-to)784-790
Number of pages7
JournalTransplantation
Volume86
Issue number6
DOIs
StatePublished - Sep 27 2008

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Organ Transplantation
Hepatocellular Carcinoma
Incidence
Confidence Intervals
Transplants
Registries
Hepatitis Viruses
Liver
Virus Diseases
Hepatitis B
Hepacivirus
Diabetes Mellitus
Kidney
Lung
Population

Keywords

  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Immunosuppression
  • Solid organ transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Incidence and risk factors for hepatocellular carcinoma after solid organ transplantation. / Hoffmann, Christopher; Subramanian, Aruna K.; Cameron, Andrew M; Engels, Eric A.

In: Transplantation, Vol. 86, No. 6, 27.09.2008, p. 784-790.

Research output: Contribution to journalArticle

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