TY - JOUR
T1 - Incidence and predictors of human immunodeficiency virus type 1 seroconversion in patients attending sexually transmitted disease clinics in India
AU - Mehendale, Sanjay M.
AU - Rodrigues, Jeanette J.
AU - Brookmeyer, Ronald S.
AU - Gangakhedkar, Raman R.
AU - Divekar, Anand D.
AU - Gokhale, Manjusha R.
AU - Risbud, Arun R.
AU - Paranjape, Ramesh S.
AU - Shepherd, Mary E.
AU - Rompalo, Ann E.
AU - Tolat, Sunil N.
AU - Jadhav, Vijay D.
AU - Quinn, Thomas C.
AU - Bollinger, Robert C.
N1 - Funding Information:
Informed consent was obtained from all study participants. This project was reviewed and approved by the institutional review boards of Johns Hopkins Medical School and National AIDS Research Institute. An Assurance of Compliance with US Health and Human Services Regulations for Protection of Human Research Subjects has also been submitted and approved by the National Institutes of Health, Office for Protection from Research Risks.
Funding Information:
Financial support: National Institutes of Health (NIH; AI-33879, RR-00722); NIH-Fogarty International Center, NIH, Program of International Training Grants in Epidemiology Related to AIDS (D43-TWOOOO); Family Health International (FHI) with funds from National Institute of Allergy and Infectious Diseases (NIAID), NIH, although the views expressed in this article do not necessarily reflect those of FHI or NIAID.
PY - 1995/12
Y1 - 1995/12
N2 - The first estimates of the seroincidence of human immunodeficiency virus type 1 (HIV-1) and of the risk factors for seroconversion in a cohort of high-risk patients attending sexually transmitted disease (STD) clinics in India are reported. Between 1993 and 1995, 851 HIV-1-seronegative persons were evaluated prospectivelyevery 3 months for HIV infection and biologic and behavioral characteristics. The overall incidence of HIV-1 was 10.21100 person-years (95% confidence interval, 7.9-13.1). The incidence among commercial sex workers (CSWs) was 26.11100 person-years, compared with 8.4 among non-CSWs. Recurrent genital ulcer disease and urethritis or cervicitis during the follow-up period were independently associated with a 7- (P <.001) and 3-fold (P =.06) increased risk of HIV-1 seroconversion, respectively. Because of the association of recurrent ulcerative and nonulcerative STDs with HIV-1 seroconversion in this setting, behavioral and biologic measures directed at the prevention and control of STDs would be expected to greatly reduce the transmission of HIV-1 infection in similar high-risk groups.
AB - The first estimates of the seroincidence of human immunodeficiency virus type 1 (HIV-1) and of the risk factors for seroconversion in a cohort of high-risk patients attending sexually transmitted disease (STD) clinics in India are reported. Between 1993 and 1995, 851 HIV-1-seronegative persons were evaluated prospectivelyevery 3 months for HIV infection and biologic and behavioral characteristics. The overall incidence of HIV-1 was 10.21100 person-years (95% confidence interval, 7.9-13.1). The incidence among commercial sex workers (CSWs) was 26.11100 person-years, compared with 8.4 among non-CSWs. Recurrent genital ulcer disease and urethritis or cervicitis during the follow-up period were independently associated with a 7- (P <.001) and 3-fold (P =.06) increased risk of HIV-1 seroconversion, respectively. Because of the association of recurrent ulcerative and nonulcerative STDs with HIV-1 seroconversion in this setting, behavioral and biologic measures directed at the prevention and control of STDs would be expected to greatly reduce the transmission of HIV-1 infection in similar high-risk groups.
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U2 - 10.1093/infdis/172.6.1486
DO - 10.1093/infdis/172.6.1486
M3 - Article
C2 - 7594707
AN - SCOPUS:0028882663
SN - 0022-1899
VL - 172
SP - 1486
EP - 1491
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -