Incidence and Early Course of Retlnonathy of Prematurity

Earl A. Palmer, John T. Flynn, Robert J. Hardy, Dale L. Phelps, Cynthia L. Phillips, David B. Schaffer, Betty Tung, Frederick J. Elsas, Jan M. Botsford, Karen W. Braune, George Cassady, John A. Jones, James A. Kimble, Lanning Kline, Douglas Witherspoon, Malinda Young, Alan M. Roth, Byron H. Demorest, Roberta Erickson, William S. GilbertGeorgia A. Chrousos, David S. Friendly, Mohammad Jaafar, Marshall P. Keys, Martin P. Kolsky, Patricia Ann Mercer, Donna O'Neill, John F. O'Neill, Edward S. Parelhoff, Ed Perraut, A. Raymond Pilkerton, David Plotsky, John Clarkson, Gabrielle Lopez, Marilyn T. Miller, Rama Bhat, Steven B. Cohen, Cathleen Cronin, Mark Daily, Donald A. Gagliano, Richard Gieser, Betty Anne Haldi, Kristine McCulloch, David Mittelman, Tonse N. Raju, David Sheftel, Kathleen Skuran, Daniel B. Sobel, Peggy Squires, Charles Vygantas, Forrest D. Ellis, Steve Archer, Eugene M. Helveston, Ken Julian, Gayle Reed, Richard Schreiner, Charles C. Barr, David N. Adamkin, Craig H. Douglas, Gregory K. Whittington, Shirley Wilkerson, Robert A. Gordon, Carolyn Bushaw, W. Michael DeVoe, James G. Diamond, William L. Gill, Donald R. May, Jane E. Reynolds, Thomas G. Storch, Serge de Bustros, Alethia Alford, Janet Graeber, Michael X Repka, Michael T. Trese, John D. Baker, Ghaleb F. Hatem, Patricia Manatrey, Doreen Medalis, Robert C. Ramsay, C. Gail Summers, J. Douglas Cameron, Kim Chisholm, Rebecca Heikenen, Donna K. Irlbeck, Alvina M. Janda, Leslie A. Kopietz, Robin Kriedeman, Jane D. Lavoie, Molly Maxwell, Ted R. Pier, William P. Rodman, Patty Witt, Amy Woody, Paul Torrisi, Thaddeus Zak, Kathy Cohen, Rajesh J. Dave, Ernest Guillet, David Hakanson, Robert Hampton, Walter Merriam, Henry S. Metz, Ellen Pronobis, Richard Simon, Robert E. Vanderlinde, Nancy E. Wood, Donald N. Zehl, Edward Buckley, Malcolm M. Anderson, Grace Valentine, Susie Wong, Miles J. Burke, Judith C. Johnson, Gary L. Rogers, Don L. Bremer, Leandro Cordero, Rae R. Fellows, Nancy B. Hansen, Richard E. McClead, Arthur A. Aaby, Raul Banagale, Gerda I. Benda, Nancy D. Binder, William J. Brown, Joseph T. Gilhooly, Shawn Goodman, Robert K. Huston, Susan B. LaFrance, Patrick K. Lewallen, John V. McDonald, David L. Murphy, John W. Reynolds, Joseph Robertson, Andrea C. Tongue, Frank W. Bowen, Maria Delivoria-Papadopoulos, Hemant J. Desai, Gary R. Diamond, Joan M. Giannetta, Michael A. Naidoff, George J. Peckham, Jeanette R. Pleasure, Rachael Porat, Graham E. Quinn, Albert W. Biglan, David R. Brown, Bernard H. Doft, Andrew W. Eller, Louis A. Lobes, Richard A. Saunders, Linda M. Christmann, Tom L. Austin, Lesley Berkeley, James G. Ferguson, Wilson G. McWilliams, Karen W. Miller, Sharada Pai, V. Al Pakalnis, Dilip M. Purohit, Stephen S. Feman, Robert Cotton, James H. Elliott, Amy B. Law, Steven D. Steele, Rand Spencer, Priscilla M. Berry, Gary E. Fish, Dwain G. Fuller, William L. Hutton, Joel Lefer, Jean R. Manning, George E. Sanborn, William B. Snyder, David R. Stager, W. A.J. van Heuven, Marilyn B. Escobedo, Maria G. Montez, James W. Speights, Jane D. Kivlin, Susan Bracken, John Carver, Jack Dolcourt, Robert O. Hoffman, Michael Teske, A. Thomas Williams

Research output: Contribution to journalArticle

Abstract

In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.

Original languageEnglish (US)
Pages (from-to)1628-1640
Number of pages13
JournalOphthalmology
Volume98
Issue number11
DOIs
StatePublished - 1991

Fingerprint

Retinopathy of Prematurity
Incidence
Birth Weight
Retinal Vessels
Cryotherapy
Gestational Age
Multicenter Studies
Blood Vessels
Parturition

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Palmer, E. A., Flynn, J. T., Hardy, R. J., Phelps, D. L., Phillips, C. L., Schaffer, D. B., ... Williams, A. T. (1991). Incidence and Early Course of Retlnonathy of Prematurity. Ophthalmology, 98(11), 1628-1640. https://doi.org/10.1016/S0161-6420(91)32074-8

Incidence and Early Course of Retlnonathy of Prematurity. / Palmer, Earl A.; Flynn, John T.; Hardy, Robert J.; Phelps, Dale L.; Phillips, Cynthia L.; Schaffer, David B.; Tung, Betty; Elsas, Frederick J.; Botsford, Jan M.; Braune, Karen W.; Cassady, George; Jones, John A.; Kimble, James A.; Kline, Lanning; Witherspoon, Douglas; Young, Malinda; Roth, Alan M.; Demorest, Byron H.; Erickson, Roberta; Gilbert, William S.; Chrousos, Georgia A.; Friendly, David S.; Jaafar, Mohammad; Keys, Marshall P.; Kolsky, Martin P.; Mercer, Patricia Ann; O'Neill, Donna; O'Neill, John F.; Parelhoff, Edward S.; Perraut, Ed; Pilkerton, A. Raymond; Plotsky, David; Clarkson, John; Lopez, Gabrielle; Miller, Marilyn T.; Bhat, Rama; Cohen, Steven B.; Cronin, Cathleen; Daily, Mark; Gagliano, Donald A.; Gieser, Richard; Haldi, Betty Anne; McCulloch, Kristine; Mittelman, David; Raju, Tonse N.; Sheftel, David; Skuran, Kathleen; Sobel, Daniel B.; Squires, Peggy; Vygantas, Charles; Ellis, Forrest D.; Archer, Steve; Helveston, Eugene M.; Julian, Ken; Reed, Gayle; Schreiner, Richard; Barr, Charles C.; Adamkin, David N.; Douglas, Craig H.; Whittington, Gregory K.; Wilkerson, Shirley; Gordon, Robert A.; Bushaw, Carolyn; DeVoe, W. Michael; Diamond, James G.; Gill, William L.; May, Donald R.; Reynolds, Jane E.; Storch, Thomas G.; de Bustros, Serge; Alford, Alethia; Graeber, Janet; Repka, Michael X; Trese, Michael T.; Baker, John D.; Hatem, Ghaleb F.; Manatrey, Patricia; Medalis, Doreen; Ramsay, Robert C.; Gail Summers, C.; Cameron, J. Douglas; Chisholm, Kim; Heikenen, Rebecca; Irlbeck, Donna K.; Janda, Alvina M.; Kopietz, Leslie A.; Kriedeman, Robin; Lavoie, Jane D.; Maxwell, Molly; Pier, Ted R.; Rodman, William P.; Witt, Patty; Woody, Amy; Torrisi, Paul; Zak, Thaddeus; Cohen, Kathy; Dave, Rajesh J.; Guillet, Ernest; Hakanson, David; Hampton, Robert; Merriam, Walter; Metz, Henry S.; Pronobis, Ellen; Simon, Richard; Vanderlinde, Robert E.; Wood, Nancy E.; Zehl, Donald N.; Buckley, Edward; Anderson, Malcolm M.; Valentine, Grace; Wong, Susie; Burke, Miles J.; Johnson, Judith C.; Rogers, Gary L.; Bremer, Don L.; Cordero, Leandro; Fellows, Rae R.; Hansen, Nancy B.; McClead, Richard E.; Aaby, Arthur A.; Banagale, Raul; Benda, Gerda I.; Binder, Nancy D.; Brown, William J.; Gilhooly, Joseph T.; Goodman, Shawn; Huston, Robert K.; LaFrance, Susan B.; Lewallen, Patrick K.; McDonald, John V.; Murphy, David L.; Reynolds, John W.; Robertson, Joseph; Tongue, Andrea C.; Bowen, Frank W.; Delivoria-Papadopoulos, Maria; Desai, Hemant J.; Diamond, Gary R.; Giannetta, Joan M.; Naidoff, Michael A.; Peckham, George J.; Pleasure, Jeanette R.; Porat, Rachael; Quinn, Graham E.; Biglan, Albert W.; Brown, David R.; Doft, Bernard H.; Eller, Andrew W.; Lobes, Louis A.; Saunders, Richard A.; Christmann, Linda M.; Austin, Tom L.; Berkeley, Lesley; Ferguson, James G.; McWilliams, Wilson G.; Miller, Karen W.; Pai, Sharada; Al Pakalnis, V.; Purohit, Dilip M.; Feman, Stephen S.; Cotton, Robert; Elliott, James H.; Law, Amy B.; Steele, Steven D.; Spencer, Rand; Berry, Priscilla M.; Fish, Gary E.; Fuller, Dwain G.; Hutton, William L.; Lefer, Joel; Manning, Jean R.; Sanborn, George E.; Snyder, William B.; Stager, David R.; van Heuven, W. A.J.; Escobedo, Marilyn B.; Montez, Maria G.; Speights, James W.; Kivlin, Jane D.; Bracken, Susan; Carver, John; Dolcourt, Jack; Hoffman, Robert O.; Teske, Michael; Williams, A. Thomas.

In: Ophthalmology, Vol. 98, No. 11, 1991, p. 1628-1640.

Research output: Contribution to journalArticle

Palmer, EA, Flynn, JT, Hardy, RJ, Phelps, DL, Phillips, CL, Schaffer, DB, Tung, B, Elsas, FJ, Botsford, JM, Braune, KW, Cassady, G, Jones, JA, Kimble, JA, Kline, L, Witherspoon, D, Young, M, Roth, AM, Demorest, BH, Erickson, R, Gilbert, WS, Chrousos, GA, Friendly, DS, Jaafar, M, Keys, MP, Kolsky, MP, Mercer, PA, O'Neill, D, O'Neill, JF, Parelhoff, ES, Perraut, E, Pilkerton, AR, Plotsky, D, Clarkson, J, Lopez, G, Miller, MT, Bhat, R, Cohen, SB, Cronin, C, Daily, M, Gagliano, DA, Gieser, R, Haldi, BA, McCulloch, K, Mittelman, D, Raju, TN, Sheftel, D, Skuran, K, Sobel, DB, Squires, P, Vygantas, C, Ellis, FD, Archer, S, Helveston, EM, Julian, K, Reed, G, Schreiner, R, Barr, CC, Adamkin, DN, Douglas, CH, Whittington, GK, Wilkerson, S, Gordon, RA, Bushaw, C, DeVoe, WM, Diamond, JG, Gill, WL, May, DR, Reynolds, JE, Storch, TG, de Bustros, S, Alford, A, Graeber, J, Repka, MX, Trese, MT, Baker, JD, Hatem, GF, Manatrey, P, Medalis, D, Ramsay, RC, Gail Summers, C, Cameron, JD, Chisholm, K, Heikenen, R, Irlbeck, DK, Janda, AM, Kopietz, LA, Kriedeman, R, Lavoie, JD, Maxwell, M, Pier, TR, Rodman, WP, Witt, P, Woody, A, Torrisi, P, Zak, T, Cohen, K, Dave, RJ, Guillet, E, Hakanson, D, Hampton, R, Merriam, W, Metz, HS, Pronobis, E, Simon, R, Vanderlinde, RE, Wood, NE, Zehl, DN, Buckley, E, Anderson, MM, Valentine, G, Wong, S, Burke, MJ, Johnson, JC, Rogers, GL, Bremer, DL, Cordero, L, Fellows, RR, Hansen, NB, McClead, RE, Aaby, AA, Banagale, R, Benda, GI, Binder, ND, Brown, WJ, Gilhooly, JT, Goodman, S, Huston, RK, LaFrance, SB, Lewallen, PK, McDonald, JV, Murphy, DL, Reynolds, JW, Robertson, J, Tongue, AC, Bowen, FW, Delivoria-Papadopoulos, M, Desai, HJ, Diamond, GR, Giannetta, JM, Naidoff, MA, Peckham, GJ, Pleasure, JR, Porat, R, Quinn, GE, Biglan, AW, Brown, DR, Doft, BH, Eller, AW, Lobes, LA, Saunders, RA, Christmann, LM, Austin, TL, Berkeley, L, Ferguson, JG, McWilliams, WG, Miller, KW, Pai, S, Al Pakalnis, V, Purohit, DM, Feman, SS, Cotton, R, Elliott, JH, Law, AB, Steele, SD, Spencer, R, Berry, PM, Fish, GE, Fuller, DG, Hutton, WL, Lefer, J, Manning, JR, Sanborn, GE, Snyder, WB, Stager, DR, van Heuven, WAJ, Escobedo, MB, Montez, MG, Speights, JW, Kivlin, JD, Bracken, S, Carver, J, Dolcourt, J, Hoffman, RO, Teske, M & Williams, AT 1991, 'Incidence and Early Course of Retlnonathy of Prematurity', Ophthalmology, vol. 98, no. 11, pp. 1628-1640. https://doi.org/10.1016/S0161-6420(91)32074-8
Palmer EA, Flynn JT, Hardy RJ, Phelps DL, Phillips CL, Schaffer DB et al. Incidence and Early Course of Retlnonathy of Prematurity. Ophthalmology. 1991;98(11):1628-1640. https://doi.org/10.1016/S0161-6420(91)32074-8
Palmer, Earl A. ; Flynn, John T. ; Hardy, Robert J. ; Phelps, Dale L. ; Phillips, Cynthia L. ; Schaffer, David B. ; Tung, Betty ; Elsas, Frederick J. ; Botsford, Jan M. ; Braune, Karen W. ; Cassady, George ; Jones, John A. ; Kimble, James A. ; Kline, Lanning ; Witherspoon, Douglas ; Young, Malinda ; Roth, Alan M. ; Demorest, Byron H. ; Erickson, Roberta ; Gilbert, William S. ; Chrousos, Georgia A. ; Friendly, David S. ; Jaafar, Mohammad ; Keys, Marshall P. ; Kolsky, Martin P. ; Mercer, Patricia Ann ; O'Neill, Donna ; O'Neill, John F. ; Parelhoff, Edward S. ; Perraut, Ed ; Pilkerton, A. Raymond ; Plotsky, David ; Clarkson, John ; Lopez, Gabrielle ; Miller, Marilyn T. ; Bhat, Rama ; Cohen, Steven B. ; Cronin, Cathleen ; Daily, Mark ; Gagliano, Donald A. ; Gieser, Richard ; Haldi, Betty Anne ; McCulloch, Kristine ; Mittelman, David ; Raju, Tonse N. ; Sheftel, David ; Skuran, Kathleen ; Sobel, Daniel B. ; Squires, Peggy ; Vygantas, Charles ; Ellis, Forrest D. ; Archer, Steve ; Helveston, Eugene M. ; Julian, Ken ; Reed, Gayle ; Schreiner, Richard ; Barr, Charles C. ; Adamkin, David N. ; Douglas, Craig H. ; Whittington, Gregory K. ; Wilkerson, Shirley ; Gordon, Robert A. ; Bushaw, Carolyn ; DeVoe, W. Michael ; Diamond, James G. ; Gill, William L. ; May, Donald R. ; Reynolds, Jane E. ; Storch, Thomas G. ; de Bustros, Serge ; Alford, Alethia ; Graeber, Janet ; Repka, Michael X ; Trese, Michael T. ; Baker, John D. ; Hatem, Ghaleb F. ; Manatrey, Patricia ; Medalis, Doreen ; Ramsay, Robert C. ; Gail Summers, C. ; Cameron, J. Douglas ; Chisholm, Kim ; Heikenen, Rebecca ; Irlbeck, Donna K. ; Janda, Alvina M. ; Kopietz, Leslie A. ; Kriedeman, Robin ; Lavoie, Jane D. ; Maxwell, Molly ; Pier, Ted R. ; Rodman, William P. ; Witt, Patty ; Woody, Amy ; Torrisi, Paul ; Zak, Thaddeus ; Cohen, Kathy ; Dave, Rajesh J. ; Guillet, Ernest ; Hakanson, David ; Hampton, Robert ; Merriam, Walter ; Metz, Henry S. ; Pronobis, Ellen ; Simon, Richard ; Vanderlinde, Robert E. ; Wood, Nancy E. ; Zehl, Donald N. ; Buckley, Edward ; Anderson, Malcolm M. ; Valentine, Grace ; Wong, Susie ; Burke, Miles J. ; Johnson, Judith C. ; Rogers, Gary L. ; Bremer, Don L. ; Cordero, Leandro ; Fellows, Rae R. ; Hansen, Nancy B. ; McClead, Richard E. ; Aaby, Arthur A. ; Banagale, Raul ; Benda, Gerda I. ; Binder, Nancy D. ; Brown, William J. ; Gilhooly, Joseph T. ; Goodman, Shawn ; Huston, Robert K. ; LaFrance, Susan B. ; Lewallen, Patrick K. ; McDonald, John V. ; Murphy, David L. ; Reynolds, John W. ; Robertson, Joseph ; Tongue, Andrea C. ; Bowen, Frank W. ; Delivoria-Papadopoulos, Maria ; Desai, Hemant J. ; Diamond, Gary R. ; Giannetta, Joan M. ; Naidoff, Michael A. ; Peckham, George J. ; Pleasure, Jeanette R. ; Porat, Rachael ; Quinn, Graham E. ; Biglan, Albert W. ; Brown, David R. ; Doft, Bernard H. ; Eller, Andrew W. ; Lobes, Louis A. ; Saunders, Richard A. ; Christmann, Linda M. ; Austin, Tom L. ; Berkeley, Lesley ; Ferguson, James G. ; McWilliams, Wilson G. ; Miller, Karen W. ; Pai, Sharada ; Al Pakalnis, V. ; Purohit, Dilip M. ; Feman, Stephen S. ; Cotton, Robert ; Elliott, James H. ; Law, Amy B. ; Steele, Steven D. ; Spencer, Rand ; Berry, Priscilla M. ; Fish, Gary E. ; Fuller, Dwain G. ; Hutton, William L. ; Lefer, Joel ; Manning, Jean R. ; Sanborn, George E. ; Snyder, William B. ; Stager, David R. ; van Heuven, W. A.J. ; Escobedo, Marilyn B. ; Montez, Maria G. ; Speights, James W. ; Kivlin, Jane D. ; Bracken, Susan ; Carver, John ; Dolcourt, Jack ; Hoffman, Robert O. ; Teske, Michael ; Williams, A. Thomas. / Incidence and Early Course of Retlnonathy of Prematurity. In: Ophthalmology. 1991 ; Vol. 98, No. 11. pp. 1628-1640.
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title = "Incidence and Early Course of Retlnonathy of Prematurity",
abstract = "In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8{\%} of the infants developed ROP to some degree; 81.6{\%} for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.",
author = "Palmer, {Earl A.} and Flynn, {John T.} and Hardy, {Robert J.} and Phelps, {Dale L.} and Phillips, {Cynthia L.} and Schaffer, {David B.} and Betty Tung and Elsas, {Frederick J.} and Botsford, {Jan M.} and Braune, {Karen W.} and George Cassady and Jones, {John A.} and Kimble, {James A.} and Lanning Kline and Douglas Witherspoon and Malinda Young and Roth, {Alan M.} and Demorest, {Byron H.} and Roberta Erickson and Gilbert, {William S.} and Chrousos, {Georgia A.} and Friendly, {David S.} and Mohammad Jaafar and Keys, {Marshall P.} and Kolsky, {Martin P.} and Mercer, {Patricia Ann} and Donna O'Neill and O'Neill, {John F.} and Parelhoff, {Edward S.} and Ed Perraut and Pilkerton, {A. Raymond} and David Plotsky and John Clarkson and Gabrielle Lopez and Miller, {Marilyn T.} and Rama Bhat and Cohen, {Steven B.} and Cathleen Cronin and Mark Daily and Gagliano, {Donald A.} and Richard Gieser and Haldi, {Betty Anne} and Kristine McCulloch and David Mittelman and Raju, {Tonse N.} and David Sheftel and Kathleen Skuran and Sobel, {Daniel B.} and Peggy Squires and Charles Vygantas and Ellis, {Forrest D.} and Steve Archer and Helveston, {Eugene M.} and Ken Julian and Gayle Reed and Richard Schreiner and Barr, {Charles C.} and Adamkin, {David N.} and Douglas, {Craig H.} and Whittington, {Gregory K.} and Shirley Wilkerson and Gordon, {Robert A.} and Carolyn Bushaw and DeVoe, {W. Michael} and Diamond, {James G.} and Gill, {William L.} and May, {Donald R.} and Reynolds, {Jane E.} and Storch, {Thomas G.} and {de Bustros}, Serge and Alethia Alford and Janet Graeber and Repka, {Michael X} and Trese, {Michael T.} and Baker, {John D.} and Hatem, {Ghaleb F.} and Patricia Manatrey and Doreen Medalis and Ramsay, {Robert C.} and {Gail Summers}, C. and Cameron, {J. Douglas} and Kim Chisholm and Rebecca Heikenen and Irlbeck, {Donna K.} and Janda, {Alvina M.} and Kopietz, {Leslie A.} and Robin Kriedeman and Lavoie, {Jane D.} and Molly Maxwell and Pier, {Ted R.} and Rodman, {William P.} and Patty Witt and Amy Woody and Paul Torrisi and Thaddeus Zak and Kathy Cohen and Dave, {Rajesh J.} and Ernest Guillet and David Hakanson and Robert Hampton and Walter Merriam and Metz, {Henry S.} and Ellen Pronobis and Richard Simon and Vanderlinde, {Robert E.} and Wood, {Nancy E.} and Zehl, {Donald N.} and Edward Buckley and Anderson, {Malcolm M.} and Grace Valentine and Susie Wong and Burke, {Miles J.} and Johnson, {Judith C.} and Rogers, {Gary L.} and Bremer, {Don L.} and Leandro Cordero and Fellows, {Rae R.} and Hansen, {Nancy B.} and McClead, {Richard E.} and Aaby, {Arthur A.} and Raul Banagale and Benda, {Gerda I.} and Binder, {Nancy D.} and Brown, {William J.} and Gilhooly, {Joseph T.} and Shawn Goodman and Huston, {Robert K.} and LaFrance, {Susan B.} and Lewallen, {Patrick K.} and McDonald, {John V.} and Murphy, {David L.} and Reynolds, {John W.} and Joseph Robertson and Tongue, {Andrea C.} and Bowen, {Frank W.} and Maria Delivoria-Papadopoulos and Desai, {Hemant J.} and Diamond, {Gary R.} and Giannetta, {Joan M.} and Naidoff, {Michael A.} and Peckham, {George J.} and Pleasure, {Jeanette R.} and Rachael Porat and Quinn, {Graham E.} and Biglan, {Albert W.} and Brown, {David R.} and Doft, {Bernard H.} and Eller, {Andrew W.} and Lobes, {Louis A.} and Saunders, {Richard A.} and Christmann, {Linda M.} and Austin, {Tom L.} and Lesley Berkeley and Ferguson, {James G.} and McWilliams, {Wilson G.} and Miller, {Karen W.} and Sharada Pai and {Al Pakalnis}, V. and Purohit, {Dilip M.} and Feman, {Stephen S.} and Robert Cotton and Elliott, {James H.} and Law, {Amy B.} and Steele, {Steven D.} and Rand Spencer and Berry, {Priscilla M.} and Fish, {Gary E.} and Fuller, {Dwain G.} and Hutton, {William L.} and Joel Lefer and Manning, {Jean R.} and Sanborn, {George E.} and Snyder, {William B.} and Stager, {David R.} and {van Heuven}, {W. A.J.} and Escobedo, {Marilyn B.} and Montez, {Maria G.} and Speights, {James W.} and Kivlin, {Jane D.} and Susan Bracken and John Carver and Jack Dolcourt and Hoffman, {Robert O.} and Michael Teske and Williams, {A. Thomas}",
year = "1991",
doi = "10.1016/S0161-6420(91)32074-8",
language = "English (US)",
volume = "98",
pages = "1628--1640",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - Incidence and Early Course of Retlnonathy of Prematurity

AU - Palmer, Earl A.

AU - Flynn, John T.

AU - Hardy, Robert J.

AU - Phelps, Dale L.

AU - Phillips, Cynthia L.

AU - Schaffer, David B.

AU - Tung, Betty

AU - Elsas, Frederick J.

AU - Botsford, Jan M.

AU - Braune, Karen W.

AU - Cassady, George

AU - Jones, John A.

AU - Kimble, James A.

AU - Kline, Lanning

AU - Witherspoon, Douglas

AU - Young, Malinda

AU - Roth, Alan M.

AU - Demorest, Byron H.

AU - Erickson, Roberta

AU - Gilbert, William S.

AU - Chrousos, Georgia A.

AU - Friendly, David S.

AU - Jaafar, Mohammad

AU - Keys, Marshall P.

AU - Kolsky, Martin P.

AU - Mercer, Patricia Ann

AU - O'Neill, Donna

AU - O'Neill, John F.

AU - Parelhoff, Edward S.

AU - Perraut, Ed

AU - Pilkerton, A. Raymond

AU - Plotsky, David

AU - Clarkson, John

AU - Lopez, Gabrielle

AU - Miller, Marilyn T.

AU - Bhat, Rama

AU - Cohen, Steven B.

AU - Cronin, Cathleen

AU - Daily, Mark

AU - Gagliano, Donald A.

AU - Gieser, Richard

AU - Haldi, Betty Anne

AU - McCulloch, Kristine

AU - Mittelman, David

AU - Raju, Tonse N.

AU - Sheftel, David

AU - Skuran, Kathleen

AU - Sobel, Daniel B.

AU - Squires, Peggy

AU - Vygantas, Charles

AU - Ellis, Forrest D.

AU - Archer, Steve

AU - Helveston, Eugene M.

AU - Julian, Ken

AU - Reed, Gayle

AU - Schreiner, Richard

AU - Barr, Charles C.

AU - Adamkin, David N.

AU - Douglas, Craig H.

AU - Whittington, Gregory K.

AU - Wilkerson, Shirley

AU - Gordon, Robert A.

AU - Bushaw, Carolyn

AU - DeVoe, W. Michael

AU - Diamond, James G.

AU - Gill, William L.

AU - May, Donald R.

AU - Reynolds, Jane E.

AU - Storch, Thomas G.

AU - de Bustros, Serge

AU - Alford, Alethia

AU - Graeber, Janet

AU - Repka, Michael X

AU - Trese, Michael T.

AU - Baker, John D.

AU - Hatem, Ghaleb F.

AU - Manatrey, Patricia

AU - Medalis, Doreen

AU - Ramsay, Robert C.

AU - Gail Summers, C.

AU - Cameron, J. Douglas

AU - Chisholm, Kim

AU - Heikenen, Rebecca

AU - Irlbeck, Donna K.

AU - Janda, Alvina M.

AU - Kopietz, Leslie A.

AU - Kriedeman, Robin

AU - Lavoie, Jane D.

AU - Maxwell, Molly

AU - Pier, Ted R.

AU - Rodman, William P.

AU - Witt, Patty

AU - Woody, Amy

AU - Torrisi, Paul

AU - Zak, Thaddeus

AU - Cohen, Kathy

AU - Dave, Rajesh J.

AU - Guillet, Ernest

AU - Hakanson, David

AU - Hampton, Robert

AU - Merriam, Walter

AU - Metz, Henry S.

AU - Pronobis, Ellen

AU - Simon, Richard

AU - Vanderlinde, Robert E.

AU - Wood, Nancy E.

AU - Zehl, Donald N.

AU - Buckley, Edward

AU - Anderson, Malcolm M.

AU - Valentine, Grace

AU - Wong, Susie

AU - Burke, Miles J.

AU - Johnson, Judith C.

AU - Rogers, Gary L.

AU - Bremer, Don L.

AU - Cordero, Leandro

AU - Fellows, Rae R.

AU - Hansen, Nancy B.

AU - McClead, Richard E.

AU - Aaby, Arthur A.

AU - Banagale, Raul

AU - Benda, Gerda I.

AU - Binder, Nancy D.

AU - Brown, William J.

AU - Gilhooly, Joseph T.

AU - Goodman, Shawn

AU - Huston, Robert K.

AU - LaFrance, Susan B.

AU - Lewallen, Patrick K.

AU - McDonald, John V.

AU - Murphy, David L.

AU - Reynolds, John W.

AU - Robertson, Joseph

AU - Tongue, Andrea C.

AU - Bowen, Frank W.

AU - Delivoria-Papadopoulos, Maria

AU - Desai, Hemant J.

AU - Diamond, Gary R.

AU - Giannetta, Joan M.

AU - Naidoff, Michael A.

AU - Peckham, George J.

AU - Pleasure, Jeanette R.

AU - Porat, Rachael

AU - Quinn, Graham E.

AU - Biglan, Albert W.

AU - Brown, David R.

AU - Doft, Bernard H.

AU - Eller, Andrew W.

AU - Lobes, Louis A.

AU - Saunders, Richard A.

AU - Christmann, Linda M.

AU - Austin, Tom L.

AU - Berkeley, Lesley

AU - Ferguson, James G.

AU - McWilliams, Wilson G.

AU - Miller, Karen W.

AU - Pai, Sharada

AU - Al Pakalnis, V.

AU - Purohit, Dilip M.

AU - Feman, Stephen S.

AU - Cotton, Robert

AU - Elliott, James H.

AU - Law, Amy B.

AU - Steele, Steven D.

AU - Spencer, Rand

AU - Berry, Priscilla M.

AU - Fish, Gary E.

AU - Fuller, Dwain G.

AU - Hutton, William L.

AU - Lefer, Joel

AU - Manning, Jean R.

AU - Sanborn, George E.

AU - Snyder, William B.

AU - Stager, David R.

AU - van Heuven, W. A.J.

AU - Escobedo, Marilyn B.

AU - Montez, Maria G.

AU - Speights, James W.

AU - Kivlin, Jane D.

AU - Bracken, Susan

AU - Carver, John

AU - Dolcourt, Jack

AU - Hoffman, Robert O.

AU - Teske, Michael

AU - Williams, A. Thomas

PY - 1991

Y1 - 1991

N2 - In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.

AB - In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.

UR - http://www.scopus.com/inward/record.url?scp=0026063352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026063352&partnerID=8YFLogxK

U2 - 10.1016/S0161-6420(91)32074-8

DO - 10.1016/S0161-6420(91)32074-8

M3 - Article

C2 - 1800923

AN - SCOPUS:0026063352

VL - 98

SP - 1628

EP - 1640

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 11

ER -