Abstract
In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1628-1640 |
| Number of pages | 13 |
| Journal | Ophthalmology |
| Volume | 98 |
| Issue number | 11 |
| DOIs | |
| State | Published - 1991 |
ASJC Scopus subject areas
- Ophthalmology
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Incidence and Early Course of Retlnonathy of Prematurity. / Palmer, Earl A.; Flynn, John T.; Hardy, Robert J.; Phelps, Dale L.; Phillips, Cynthia L.; Schaffer, David B.; Tung, Betty; Elsas, Frederick J.; Botsford, Jan M.; Braune, Karen W.; Cassady, George; Jones, John A.; Kimble, James A.; Kline, Lanning; Witherspoon, Douglas; Young, Malinda; Roth, Alan M.; Demorest, Byron H.; Erickson, Roberta; Gilbert, William S.; Chrousos, Georgia A.; Friendly, David S.; Jaafar, Mohammad; Keys, Marshall P.; Kolsky, Martin P.; Mercer, Patricia Ann; O'Neill, Donna; O'Neill, John F.; Parelhoff, Edward S.; Perraut, Ed; Pilkerton, A. Raymond; Plotsky, David; Clarkson, John; Lopez, Gabrielle; Miller, Marilyn T.; Bhat, Rama; Cohen, Steven B.; Cronin, Cathleen; Daily, Mark; Gagliano, Donald A.; Gieser, Richard; Haldi, Betty Anne; McCulloch, Kristine; Mittelman, David; Raju, Tonse N.; Sheftel, David; Skuran, Kathleen; Sobel, Daniel B.; Squires, Peggy; Vygantas, Charles; Ellis, Forrest D.; Archer, Steve; Helveston, Eugene M.; Julian, Ken; Reed, Gayle; Schreiner, Richard; Barr, Charles C.; Adamkin, David N.; Douglas, Craig H.; Whittington, Gregory K.; Wilkerson, Shirley; Gordon, Robert A.; Bushaw, Carolyn; DeVoe, W. Michael; Diamond, James G.; Gill, William L.; May, Donald R.; Reynolds, Jane E.; Storch, Thomas G.; de Bustros, Serge; Alford, Alethia; Graeber, Janet; Repka, Michael X.; Trese, Michael T.; Baker, John D.; Hatem, Ghaleb F.; Manatrey, Patricia; Medalis, Doreen; Ramsay, Robert C.; Gail Summers, C.; Cameron, J. Douglas; Chisholm, Kim; Heikenen, Rebecca; Irlbeck, Donna K.; Janda, Alvina M.; Kopietz, Leslie A.; Kriedeman, Robin; Lavoie, Jane D.; Maxwell, Molly; Pier, Ted R.; Rodman, William P.; Witt, Patty; Woody, Amy; Torrisi, Paul; Zak, Thaddeus; Cohen, Kathy; Dave, Rajesh J.; Guillet, Ernest; Hakanson, David; Hampton, Robert; Merriam, Walter; Metz, Henry S.; Pronobis, Ellen; Simon, Richard; Vanderlinde, Robert E.; Wood, Nancy E.; Zehl, Donald N.; Buckley, Edward; Anderson, Malcolm M.; Valentine, Grace; Wong, Susie; Burke, Miles J.; Johnson, Judith C.; Rogers, Gary L.; Bremer, Don L.; Cordero, Leandro; Fellows, Rae R.; Hansen, Nancy B.; McClead, Richard E.; Aaby, Arthur A.; Banagale, Raul; Benda, Gerda I.; Binder, Nancy D.; Brown, William J.; Gilhooly, Joseph T.; Goodman, Shawn; Huston, Robert K.; LaFrance, Susan B.; Lewallen, Patrick K.; McDonald, John V.; Murphy, David L.; Reynolds, John W.; Robertson, Joseph; Tongue, Andrea C.; Bowen, Frank W.; Delivoria-Papadopoulos, Maria; Desai, Hemant J.; Diamond, Gary R.; Giannetta, Joan M.; Naidoff, Michael A.; Peckham, George J.; Pleasure, Jeanette R.; Porat, Rachael; Quinn, Graham E.; Biglan, Albert W.; Brown, David R.; Doft, Bernard H.; Eller, Andrew W.; Lobes, Louis A.; Saunders, Richard A.; Christmann, Linda M.; Austin, Tom L.; Berkeley, Lesley; Ferguson, James G.; McWilliams, Wilson G.; Miller, Karen W.; Pai, Sharada; Al Pakalnis, V.; Purohit, Dilip M.; Feman, Stephen S.; Cotton, Robert; Elliott, James H.; Law, Amy B.; Steele, Steven D.; Spencer, Rand; Berry, Priscilla M.; Fish, Gary E.; Fuller, Dwain G.; Hutton, William L.; Lefer, Joel; Manning, Jean R.; Sanborn, George E.; Snyder, William B.; Stager, David R.; van Heuven, W. A.J.; Escobedo, Marilyn B.; Montez, Maria G.; Speights, James W.; Kivlin, Jane D.; Bracken, Susan; Carver, John; Dolcourt, Jack; Hoffman, Robert O.; Teske, Michael; Williams, A. Thomas.
In: Ophthalmology, Vol. 98, No. 11, 1991, p. 1628-1640.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Incidence and Early Course of Retlnonathy of Prematurity
AU - Palmer, Earl A.
AU - Flynn, John T.
AU - Hardy, Robert J.
AU - Phelps, Dale L.
AU - Phillips, Cynthia L.
AU - Schaffer, David B.
AU - Tung, Betty
AU - Elsas, Frederick J.
AU - Botsford, Jan M.
AU - Braune, Karen W.
AU - Cassady, George
AU - Jones, John A.
AU - Kimble, James A.
AU - Kline, Lanning
AU - Witherspoon, Douglas
AU - Young, Malinda
AU - Roth, Alan M.
AU - Demorest, Byron H.
AU - Erickson, Roberta
AU - Gilbert, William S.
AU - Chrousos, Georgia A.
AU - Friendly, David S.
AU - Jaafar, Mohammad
AU - Keys, Marshall P.
AU - Kolsky, Martin P.
AU - Mercer, Patricia Ann
AU - O'Neill, Donna
AU - O'Neill, John F.
AU - Parelhoff, Edward S.
AU - Perraut, Ed
AU - Pilkerton, A. Raymond
AU - Plotsky, David
AU - Clarkson, John
AU - Lopez, Gabrielle
AU - Miller, Marilyn T.
AU - Bhat, Rama
AU - Cohen, Steven B.
AU - Cronin, Cathleen
AU - Daily, Mark
AU - Gagliano, Donald A.
AU - Gieser, Richard
AU - Haldi, Betty Anne
AU - McCulloch, Kristine
AU - Mittelman, David
AU - Raju, Tonse N.
AU - Sheftel, David
AU - Skuran, Kathleen
AU - Sobel, Daniel B.
AU - Squires, Peggy
AU - Vygantas, Charles
AU - Ellis, Forrest D.
AU - Archer, Steve
AU - Helveston, Eugene M.
AU - Julian, Ken
AU - Reed, Gayle
AU - Schreiner, Richard
AU - Barr, Charles C.
AU - Adamkin, David N.
AU - Douglas, Craig H.
AU - Whittington, Gregory K.
AU - Wilkerson, Shirley
AU - Gordon, Robert A.
AU - Bushaw, Carolyn
AU - DeVoe, W. Michael
AU - Diamond, James G.
AU - Gill, William L.
AU - May, Donald R.
AU - Reynolds, Jane E.
AU - Storch, Thomas G.
AU - de Bustros, Serge
AU - Alford, Alethia
AU - Graeber, Janet
AU - Repka, Michael X.
AU - Trese, Michael T.
AU - Baker, John D.
AU - Hatem, Ghaleb F.
AU - Manatrey, Patricia
AU - Medalis, Doreen
AU - Ramsay, Robert C.
AU - Gail Summers, C.
AU - Cameron, J. Douglas
AU - Chisholm, Kim
AU - Heikenen, Rebecca
AU - Irlbeck, Donna K.
AU - Janda, Alvina M.
AU - Kopietz, Leslie A.
AU - Kriedeman, Robin
AU - Lavoie, Jane D.
AU - Maxwell, Molly
AU - Pier, Ted R.
AU - Rodman, William P.
AU - Witt, Patty
AU - Woody, Amy
AU - Torrisi, Paul
AU - Zak, Thaddeus
AU - Cohen, Kathy
AU - Dave, Rajesh J.
AU - Guillet, Ernest
AU - Hakanson, David
AU - Hampton, Robert
AU - Merriam, Walter
AU - Metz, Henry S.
AU - Pronobis, Ellen
AU - Simon, Richard
AU - Vanderlinde, Robert E.
AU - Wood, Nancy E.
AU - Zehl, Donald N.
AU - Buckley, Edward
AU - Anderson, Malcolm M.
AU - Valentine, Grace
AU - Wong, Susie
AU - Burke, Miles J.
AU - Johnson, Judith C.
AU - Rogers, Gary L.
AU - Bremer, Don L.
AU - Cordero, Leandro
AU - Fellows, Rae R.
AU - Hansen, Nancy B.
AU - McClead, Richard E.
AU - Aaby, Arthur A.
AU - Banagale, Raul
AU - Benda, Gerda I.
AU - Binder, Nancy D.
AU - Brown, William J.
AU - Gilhooly, Joseph T.
AU - Goodman, Shawn
AU - Huston, Robert K.
AU - LaFrance, Susan B.
AU - Lewallen, Patrick K.
AU - McDonald, John V.
AU - Murphy, David L.
AU - Reynolds, John W.
AU - Robertson, Joseph
AU - Tongue, Andrea C.
AU - Bowen, Frank W.
AU - Delivoria-Papadopoulos, Maria
AU - Desai, Hemant J.
AU - Diamond, Gary R.
AU - Giannetta, Joan M.
AU - Naidoff, Michael A.
AU - Peckham, George J.
AU - Pleasure, Jeanette R.
AU - Porat, Rachael
AU - Quinn, Graham E.
AU - Biglan, Albert W.
AU - Brown, David R.
AU - Doft, Bernard H.
AU - Eller, Andrew W.
AU - Lobes, Louis A.
AU - Saunders, Richard A.
AU - Christmann, Linda M.
AU - Austin, Tom L.
AU - Berkeley, Lesley
AU - Ferguson, James G.
AU - McWilliams, Wilson G.
AU - Miller, Karen W.
AU - Pai, Sharada
AU - Al Pakalnis, V.
AU - Purohit, Dilip M.
AU - Feman, Stephen S.
AU - Cotton, Robert
AU - Elliott, James H.
AU - Law, Amy B.
AU - Steele, Steven D.
AU - Spencer, Rand
AU - Berry, Priscilla M.
AU - Fish, Gary E.
AU - Fuller, Dwain G.
AU - Hutton, William L.
AU - Lefer, Joel
AU - Manning, Jean R.
AU - Sanborn, George E.
AU - Snyder, William B.
AU - Stager, David R.
AU - van Heuven, W. A.J.
AU - Escobedo, Marilyn B.
AU - Montez, Maria G.
AU - Speights, James W.
AU - Kivlin, Jane D.
AU - Bracken, Susan
AU - Carver, John
AU - Dolcourt, Jack
AU - Hoffman, Robert O.
AU - Teske, Michael
AU - Williams, A. Thomas
PY - 1991
Y1 - 1991
N2 - In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.
AB - In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP.
UR - http://www.scopus.com/inward/record.url?scp=0026063352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026063352&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(91)32074-8
DO - 10.1016/S0161-6420(91)32074-8
M3 - Article
C2 - 1800923
AN - SCOPUS:0026063352
VL - 98
SP - 1628
EP - 1640
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 11
ER -