Incidence and Contemporary Management of Delayed Bleeding Following Pancreaticoduodenectomy

Joseph R. Habib, Shanshan Gao, Ahn Joon Young, Elie Ghabi, Aslam Ejaz, William Burns, Richard Burkhart, Matthew Weiss, Christopher L. Wolfgang, John L. Cameron, Robert Liddell, Christos Georgiades, Kelvin Hong, Jin He, Kelly J. Lafaro

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Delayed bleeding after pancreaticoduodenectomy (PD) is a life-threatening complication. However, the optimal management remains unclear. We summarize our experience of the management of delayed bleeding after PD and define the outcomes associated with different types of management. Methods: All patients who underwent a PD between January 1987 and June 2020 at Johns Hopkins University were retrospectively reviewed. Delayed bleeding was defined as bleeding on or after postoperative day 5 following PD. Incidence, outcomes, and trends were reported. Results: Among the 6201 patients that underwent PD, delayed bleeding occurred in 130 (2.1%) at a median of 12 days (IQR: 9, 24) postoperation. The pattern of bleeding was classified as intraluminal (51.5%), extraluminal (40.8%), and mixed (7.7%). A clinically relevant postoperative pancreatic fistula and an intraabdominal abscess preceded the delayed bleeding in 43.1% and 31.5% of cases, respectively. Arterial pseudoaneurysm or bleeding from peripancreatic vessels was the most common reason (54.6%) with the gastroduodenal artery being the most common source (18.5%). Endoscopy, angiography, and reoperation were performed as a first-line approach in 35.4%, 52.3%, and 6.2% of patients, respectively. The overall mortality was 16.2% and decreased over the study period (p < 0.01). Conclusions: Delayed bleeding following PD remains a life-threatening complication. The most common location of delayed bleeding is from the gastroduodenal artery. Angiography with embolization should be the initial approach for urgent bleeding with surgical re-exploration reserved for unstable patients or failed control of bleeding after interventional angiography or endoscopy.

Original languageEnglish (US)
Pages (from-to)1161-1171
Number of pages11
JournalWorld journal of surgery
Volume46
Issue number5
DOIs
StatePublished - May 2022

ASJC Scopus subject areas

  • Surgery

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