Incidence and clinical significance of high-grade prostatic intraepithelial neoplasia in turp specimens

Paul B. Gaudin, Isabell A. Sesterhenn, Kirk J. Wojno, F. K. Mostofi, Jonathan Ira Epstein

Research output: Contribution to journalArticle

Abstract

Objectives. To determine the incidence and clinical significance of high-grade prostatic intraepithelial neoplasia (PIN) in specimens obtained from transurethral resection of the prostate (TURP). Methods. All TURP specimens accessioned to the general surgical pathology service of the Johns Hopkins Hospital (JHH) from March 1984 through December 1987 that did not contain adenocarcinoma of the prostate were reviewed for the presence of high-grade PIN (PIN 2 and PIN 3). These cases were supplemented with cases from the consultation files of the JHH, the Armed Forces Institute of Pathology, and the University of Michigan Hospitals. In total, 85 cases of high-grade PIN in TURP specimens were identified. Results. The mean age of the patients at the time of TURP was 70 years and the median age was 71 years (range 50 to 89). Sixty-three patients (74%) were 65 years of age or older, 45 patients (53%) were at least 70 years of age, and 14 patients (16%) were 60 years of age or younger. Adenocarcinoma of the prostate was discovered in 9 (22%) of 41 patients with follow-up information. Based on material from JHH, the incidence of high-grade PIN was 2.3% in all TURP specimens and 3.2% in those without invasive carcinoma. Conclusions. High-grade PIN on TURP is relatively uncommon and is diagnosed in an elderly population. Patients with high-grade PIN on TURP appear to be at increased risk of developing prostatic carcinoma, although not to the same degree as patients with high-grade PIN on needle biopsy.

Original languageEnglish (US)
Pages (from-to)558-563
Number of pages6
JournalUrology
Volume49
Issue number4
DOIs
StatePublished - Apr 1997
Externally publishedYes

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Prostatic Intraepithelial Neoplasia
Transurethral Resection of Prostate
Incidence
Prostate
Adenocarcinoma
Carcinoma
Surgical Pathology
Needle Biopsy
Referral and Consultation
Pathology

ASJC Scopus subject areas

  • Urology

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Incidence and clinical significance of high-grade prostatic intraepithelial neoplasia in turp specimens. / Gaudin, Paul B.; Sesterhenn, Isabell A.; Wojno, Kirk J.; Mostofi, F. K.; Epstein, Jonathan Ira.

In: Urology, Vol. 49, No. 4, 04.1997, p. 558-563.

Research output: Contribution to journalArticle

Gaudin, Paul B. ; Sesterhenn, Isabell A. ; Wojno, Kirk J. ; Mostofi, F. K. ; Epstein, Jonathan Ira. / Incidence and clinical significance of high-grade prostatic intraepithelial neoplasia in turp specimens. In: Urology. 1997 ; Vol. 49, No. 4. pp. 558-563.
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abstract = "Objectives. To determine the incidence and clinical significance of high-grade prostatic intraepithelial neoplasia (PIN) in specimens obtained from transurethral resection of the prostate (TURP). Methods. All TURP specimens accessioned to the general surgical pathology service of the Johns Hopkins Hospital (JHH) from March 1984 through December 1987 that did not contain adenocarcinoma of the prostate were reviewed for the presence of high-grade PIN (PIN 2 and PIN 3). These cases were supplemented with cases from the consultation files of the JHH, the Armed Forces Institute of Pathology, and the University of Michigan Hospitals. In total, 85 cases of high-grade PIN in TURP specimens were identified. Results. The mean age of the patients at the time of TURP was 70 years and the median age was 71 years (range 50 to 89). Sixty-three patients (74{\%}) were 65 years of age or older, 45 patients (53{\%}) were at least 70 years of age, and 14 patients (16{\%}) were 60 years of age or younger. Adenocarcinoma of the prostate was discovered in 9 (22{\%}) of 41 patients with follow-up information. Based on material from JHH, the incidence of high-grade PIN was 2.3{\%} in all TURP specimens and 3.2{\%} in those without invasive carcinoma. Conclusions. High-grade PIN on TURP is relatively uncommon and is diagnosed in an elderly population. Patients with high-grade PIN on TURP appear to be at increased risk of developing prostatic carcinoma, although not to the same degree as patients with high-grade PIN on needle biopsy.",
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AU - Mostofi, F. K.

AU - Epstein, Jonathan Ira

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N2 - Objectives. To determine the incidence and clinical significance of high-grade prostatic intraepithelial neoplasia (PIN) in specimens obtained from transurethral resection of the prostate (TURP). Methods. All TURP specimens accessioned to the general surgical pathology service of the Johns Hopkins Hospital (JHH) from March 1984 through December 1987 that did not contain adenocarcinoma of the prostate were reviewed for the presence of high-grade PIN (PIN 2 and PIN 3). These cases were supplemented with cases from the consultation files of the JHH, the Armed Forces Institute of Pathology, and the University of Michigan Hospitals. In total, 85 cases of high-grade PIN in TURP specimens were identified. Results. The mean age of the patients at the time of TURP was 70 years and the median age was 71 years (range 50 to 89). Sixty-three patients (74%) were 65 years of age or older, 45 patients (53%) were at least 70 years of age, and 14 patients (16%) were 60 years of age or younger. Adenocarcinoma of the prostate was discovered in 9 (22%) of 41 patients with follow-up information. Based on material from JHH, the incidence of high-grade PIN was 2.3% in all TURP specimens and 3.2% in those without invasive carcinoma. Conclusions. High-grade PIN on TURP is relatively uncommon and is diagnosed in an elderly population. Patients with high-grade PIN on TURP appear to be at increased risk of developing prostatic carcinoma, although not to the same degree as patients with high-grade PIN on needle biopsy.

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