TY - JOUR
T1 - Incidence and clinical impact of fluoroquinolone-resistant Escherichia coli in the faecal flora of cancer patients treated with high dose chemotherapy and ciprofloxacin prophylaxis
AU - Perea, Sofia
AU - Hidalgo, Manuel
AU - Arcediano, Alberto
AU - Ramos, Maria Jose
AU - Gomez, Carlos
AU - Hornedo, Javier
AU - Lumbreras, Carlos
AU - Folgueira, Dolores
AU - Cortes-Funes, Hernan
AU - Rodriguez-Noriega, Antonio
PY - 1999
Y1 - 1999
N2 - This study evaluated the susceptibility of Escherichia coli to quinolones in 72 stool samples collected from 31 patients with solid tumours who had undergone high dose chemotherapy (HDC) and peripheral blood stem-cell (PBSC) rescue with ciprofloxacin prophylaxis. Samples were obtained at admission, after completing prophylaxis and three months later. All E. coli strains isolated from baseline samples were susceptible to quinolones. Fluoroquinolone-resistant E. coli strains were isolated in 10 (32%) patients in the second sample. In eight of these patients isolates were susceptible 3 months later. No patient developed infection due to fluorquinolone-resistant E. coli. No differences were observed in outcome between patients with susceptible and resistant flora.
AB - This study evaluated the susceptibility of Escherichia coli to quinolones in 72 stool samples collected from 31 patients with solid tumours who had undergone high dose chemotherapy (HDC) and peripheral blood stem-cell (PBSC) rescue with ciprofloxacin prophylaxis. Samples were obtained at admission, after completing prophylaxis and three months later. All E. coli strains isolated from baseline samples were susceptible to quinolones. Fluoroquinolone-resistant E. coli strains were isolated in 10 (32%) patients in the second sample. In eight of these patients isolates were susceptible 3 months later. No patient developed infection due to fluorquinolone-resistant E. coli. No differences were observed in outcome between patients with susceptible and resistant flora.
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U2 - 10.1093/jac/44.1.117
DO - 10.1093/jac/44.1.117
M3 - Article
C2 - 10459819
AN - SCOPUS:0032837575
SN - 0305-7453
VL - 44
SP - 117
EP - 120
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 1
ER -