TY - JOUR
T1 - Incentive processing in congenital adrenal hyperplasia (CAH)
T2 - A reward-based antisaccade study
AU - Mueller, Sven C.
AU - Daniele, Teresa
AU - MacIntyre, Jessica
AU - Korelitz, Katherine
AU - Carlisi, Christina
AU - Hardin, Michael G.
AU - Van Ryzin, Carol
AU - Merke, Deborah P.
AU - Ernst, Monique
N1 - Funding Information:
This work was supported (in part) by The Intramural Research Programs of the National Institute of Mental Health, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institutes of Health Clinical Center. We also acknowledge the support of Ghent University (Multidisciplinary Research Partnership “The integrative neuroscience of behavioral control”).
PY - 2013/5
Y1 - 2013/5
N2 - Little is known about how steroid hormones contribute to the beneficial effect of incentives on cognitive control during adolescent development. In this study, 27 adolescents with Congenital Adrenal Hyperplasia (CAH, mean age 15.6 years, 12 female), a disorder of cortisol deficiency and androgen excess, and 36 healthy participants (mean age 16.3 years, 18 female) completed a reward-based antisaccade task. In this mixed-saccade task, participants performed eye movements towards (prosaccades) or away (antisaccades) from a peripherally occuring stimulus. On incentive trials, monetary reward was provided for correct performance, while no such reward was provided on no-incentive trials. Consistent with the hypothesis, the results showed that healthy, but not CAH adolescents, significantly improved their inhibitory control (antisaccade accuracy) during incentive trials relative to no-incentive trials. These findings were not driven by severity of CAH (salt wasters vs. simple virilizers), individual hormone levels, sex, age-at-diagnosis, or medication type (dexamethasone vs. hydrocortisone). In addition, no significant differences between groups were found on orienting responses (prosaccades). Additional analyses revealed an impact of glucocorticoid (GC) dosage, such that higher GC dose predicted better antisaccade performance. However, this effect did not impact incentive processing. The data are discussed within the context of steroid hormone mediated effects on cognitive control and reward processing.
AB - Little is known about how steroid hormones contribute to the beneficial effect of incentives on cognitive control during adolescent development. In this study, 27 adolescents with Congenital Adrenal Hyperplasia (CAH, mean age 15.6 years, 12 female), a disorder of cortisol deficiency and androgen excess, and 36 healthy participants (mean age 16.3 years, 18 female) completed a reward-based antisaccade task. In this mixed-saccade task, participants performed eye movements towards (prosaccades) or away (antisaccades) from a peripherally occuring stimulus. On incentive trials, monetary reward was provided for correct performance, while no such reward was provided on no-incentive trials. Consistent with the hypothesis, the results showed that healthy, but not CAH adolescents, significantly improved their inhibitory control (antisaccade accuracy) during incentive trials relative to no-incentive trials. These findings were not driven by severity of CAH (salt wasters vs. simple virilizers), individual hormone levels, sex, age-at-diagnosis, or medication type (dexamethasone vs. hydrocortisone). In addition, no significant differences between groups were found on orienting responses (prosaccades). Additional analyses revealed an impact of glucocorticoid (GC) dosage, such that higher GC dose predicted better antisaccade performance. However, this effect did not impact incentive processing. The data are discussed within the context of steroid hormone mediated effects on cognitive control and reward processing.
KW - Adolescence
KW - Androgen
KW - Cortisol
KW - Development
KW - Inhibitory control
KW - Sex steroids
KW - Testosterone
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U2 - 10.1016/j.psyneuen.2012.08.001
DO - 10.1016/j.psyneuen.2012.08.001
M3 - Article
C2 - 22917623
AN - SCOPUS:84876081115
SN - 0306-4530
VL - 38
SP - 716
EP - 721
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
IS - 5
ER -