Inactivation of viruses with a femtosecond laser via impulsive stimulated Raman scattering

K. T. Tsen, Shaw Wei D Tsen, Chih Long Chang, Chien-Fu Hung, Tzyy Choou Wu, B. Ramakrishna, K. Mossman, Juliann G. Kiang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The inactivation of viruses such as M13 bateriophages subject to excitations by a very low power visible femtosecond laser has been studied. Our experimental results show that for a visible femtosecond laser having λ = 425nm and a pulse width of 100 fs, the M13 bacteriophages are inactivated when the laser power density is greater than or equal to 50 MW / cm2. The functionality of M13 bacteriophages has been shown to be critically dependent on the pulse width as well as power density of the excitation laser. Our work demonstrates that by using a very low power visible femtosecond laser, it is plausible to inactivate viruses such as the M13 bacteriophages through Impulsive Stimulated Raman Scattering (ISRS) process. These experimental findings lay down the foundation for a novel new avenue of selectively inactivating microorganisms while leaving the sensitive materials unharmed by manipulating and controlling with femtosecond laser systems.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6854
DOIs
Publication statusPublished - 2008
EventOptical Interactions with Tissue and Cells XIX - San Jose, CA, United States
Duration: Jan 21 2008Jan 23 2008

Other

OtherOptical Interactions with Tissue and Cells XIX
CountryUnited States
CitySan Jose, CA
Period1/21/081/23/08

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Keywords

  • Femtosecond laser
  • Impulsive stimulated Raman scattering
  • Inactivation
  • M13 phage

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Tsen, K. T., Tsen, S. W. D., Chang, C. L., Hung, C-F., Wu, T. C., Ramakrishna, B., ... Kiang, J. G. (2008). Inactivation of viruses with a femtosecond laser via impulsive stimulated Raman scattering. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6854). [68540N] https://doi.org/10.1117/12.762324