Inactivation of tumor suppressor genes: Choice between genetic and epigenetic routes

Wen Yong Chen, Stephen B. Baylin

Research output: Contribution to journalShort surveypeer-review

Abstract

Inactivation of tumor suppressor genes can occur via epigenetic or genetic mechanisms. The reasons underlying this choice of gene inactivation routes during tumorigenesis have not been clarified, nor have the precise roles in cancer evolution for genes which are solely affected by epigenetically mediated loss of function. Here we discuss a mouse model in which the disruption of Hic1, a gene solely involved with epigenetic silencing in human cancer, can markedly influence the disruption of the powerful tumor suppressor gene, p53, in determining malignant tumor incidence, spectrum and virulence. Furthermore, the mechanism for inactivation of Hic1 in tumors produced can be switched from an epigenetic to a genetic mode depending on how the Hic1 and p53 knockouts are localized on mouse chromosome 11. The value of such a model and the implications of the findings for choice of epigenetically versus genetically determined loss of gene function in cancer are discussed.

Original languageEnglish (US)
Pages (from-to)10-12
Number of pages3
JournalCell Cycle
Volume4
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

Keywords

  • Chromatin
  • Epigenetics
  • Genetics
  • HIC1
  • Histone deacetylation
  • Methylation
  • Tumor suppressor
  • p53

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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