TY - JOUR
T1 - Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability
AU - Markowitz, Sanford
AU - Wang, Jing
AU - Myeroff, Lois
AU - Parsons, Ramon
AU - Sun, Luzhe
AU - Lutterbaugh, James
AU - Fan, Robert S.
AU - Zborowska, Elizabeth
AU - Kinzler, Kenneth W.
AU - Vogelstein, Bert
AU - Brattain, Michael
AU - Willson, James K.V.
PY - 1995
Y1 - 1995
N2 - Transforming growth factor-β (TGF-β) is a potent inhibitor of epithelial cell growth. Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-β receptor (RII) gene. Eight such examples, due to three different mutations, were identified. The mutations were clustered within small repeated sequences in the RII gene, were accompanied by the absence of cell surface RII receptors, and were usually associated with small amounts of RII transcript. RII mutation, by inducing the escape of cells from TGF-β-mediated growth control, links DNA repair defects with a specific pathway of tumor progression.
AB - Transforming growth factor-β (TGF-β) is a potent inhibitor of epithelial cell growth. Human colon cancer cell lines with high rates of microsatellite instability were found to harbor mutations in the type II TGF-β receptor (RII) gene. Eight such examples, due to three different mutations, were identified. The mutations were clustered within small repeated sequences in the RII gene, were accompanied by the absence of cell surface RII receptors, and were usually associated with small amounts of RII transcript. RII mutation, by inducing the escape of cells from TGF-β-mediated growth control, links DNA repair defects with a specific pathway of tumor progression.
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U2 - 10.1126/science.7761852
DO - 10.1126/science.7761852
M3 - Article
C2 - 7761852
AN - SCOPUS:0029066689
SN - 0036-8075
VL - 268
SP - 1336
EP - 1338
JO - Science
JF - Science
IS - 5215
ER -