Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung

Montserrat Sanchez-Cespedes, Paola Parrella, Manel Esteller, Shuji Nomoto, Barry Trink, James M. Engles, William H. Westra, James G. Herman, David Sidransky

Research output: Contribution to journalArticlepeer-review

Abstract

Frequent losses of chromosome 19p have recently been observed in sporadic lung adenocarcinomas, targeting the location of a critical tumor suppressor gene. Here we performed fine mapping of the short arm of chromosome 19 and found that the LKB1/STK11 gene mapped in the minimal-deleted region. Because germ-line mutations at LKB1/STK11 result in the Peutz-Jeghers syndrome and an increased risk of cancer, we performed a detailed genetic screen of the LKB1/STK11 gene in lung tumors. We detected a high frequency of somatic alterations (mainly nonsense mutations) in primary lung adenocarcinomas and in lung cancer cell lines. Thus, our findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)3659-3662
Number of pages4
JournalCancer Research
Volume62
Issue number13
StatePublished - Jul 1 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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