Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213

J. M S Van Maanen, C. De Ruiter, P. R. Kootstra, M. V M Lafleur, J. De Vries, J. Retèl, H. M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Biologically active φX174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-φX174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.

Original languageEnglish (US)
Pages (from-to)1215-1218
Number of pages4
JournalEuropean Journal of Cancer and Clinical Oncology
Volume21
Issue number10
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213'. Together they form a unique fingerprint.

Cite this