Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213

J. M S Van Maanen; C. De Ruiter; P. R. Kootstra; M. V M Lafleur; J. De Vries; J. Retèl; H. M. Pinedo

doi:10.1016/0277-5379(85)90018-5

Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213

J. M S Van Maanen, C. De Ruiter, P. R. Kootstra, M. V M Lafleur, J. De Vries, J. Retèl, H. M. Pinedo

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Biologically active φX174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-φX174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.

Original language	English (US)
Pages (from-to)	1215-1218
Number of pages	4
Journal	European Journal of Cancer and Clinical Oncology
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/0277-5379(85)90018-5
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Oncology

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10.1016/0277-5379(85)90018-5

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title = "Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213",

abstract = "Biologically active φX174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-φX174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.",

author = "{Van Maanen}, {J. M S} and {De Ruiter}, C. and Kootstra, {P. R.} and Lafleur, {M. V M} and {De Vries}, J. and J. Ret{\`e}l and Pinedo, {H. M.}",

year = "1985",

doi = "10.1016/0277-5379(85)90018-5",

language = "English (US)",

volume = "21",

pages = "1215--1218",

journal = "European Journal of Cancer and Clinical Oncology",

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publisher = "Pergamon Press",

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T1 - Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213

AU - Van Maanen, J. M S

AU - De Ruiter, C.

AU - Kootstra, P. R.

AU - Lafleur, M. V M

AU - De Vries, J.

AU - Retèl, J.

AU - Pinedo, H. M.

PY - 1985

Y1 - 1985

N2 - Biologically active φX174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-φX174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.

AB - Biologically active φX174 DNA is inactivated by the ortho-quinone derivative of the antitumor agent VP 16-213, but not by VP 16-213 itself, VP 16-213 phenoxy radical or aqueous decomposition product(s) of the ortho-quinone. Reduction of the ortho-quinone by cytochrome P-450 reductase and NADPH results in deactivation of the ortho-quinone towards anti-φX174 DNA activity. However, compared with the parent compound VP 16-213, reduction of the ortho-quinone results in substantial damage towards DNA.

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JO - European Journal of Cancer and Clinical Oncology

JF - European Journal of Cancer and Clinical Oncology

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Inactivation of φX174 DNA by the ortho-quinone derivative or its reduction product of the antitumor agent VP 16-213

Abstract

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