TY - JOUR
T1 - Inability to empathize
T2 - Brain lesions that disrupt sharing and understanding another's emotions
AU - Hillis, Argye E.
N1 - Funding Information:
This work was supported by: National Institute of Neurological Disorders and Stroke, grant # [RO1NS47691].
PY - 2014/4
Y1 - 2014/4
N2 - Emotional empathy-the ability to recognize, share in, and make inferences about another person's emotional state-is critical for all social interactions. The neural mechanisms underlying emotional empathy have been widely studied with functional imaging of healthy participants. However, functional imaging studies reveal correlations between areas of activation and performance of a task, so that they can only reveal areas engaged in a task, rather than areas of the brain that are critical for the task. Lesion studies complement functional imaging, to identify areas necessary for a task. Impairments in emotional empathy have been mostly studied in neurological diseases with fairly diffuse injury, such as traumatic brain injury, autism and dementia. The classic 'focal lesion' is stroke. There have been scattered studies of patients with impaired empathy after stroke and other focal injury, but these studies have included small numbers of patients. This review will bring together data from these studies, to complement evidence from functional imaging. Here I review how focal lesions affect emotional empathy. I will show how lesion studies contribute to the understanding of the cognitive and neural mechanisms underlying emotional empathy, and how they contribute to the management of patients with impaired emotional empathy.
AB - Emotional empathy-the ability to recognize, share in, and make inferences about another person's emotional state-is critical for all social interactions. The neural mechanisms underlying emotional empathy have been widely studied with functional imaging of healthy participants. However, functional imaging studies reveal correlations between areas of activation and performance of a task, so that they can only reveal areas engaged in a task, rather than areas of the brain that are critical for the task. Lesion studies complement functional imaging, to identify areas necessary for a task. Impairments in emotional empathy have been mostly studied in neurological diseases with fairly diffuse injury, such as traumatic brain injury, autism and dementia. The classic 'focal lesion' is stroke. There have been scattered studies of patients with impaired empathy after stroke and other focal injury, but these studies have included small numbers of patients. This review will bring together data from these studies, to complement evidence from functional imaging. Here I review how focal lesions affect emotional empathy. I will show how lesion studies contribute to the understanding of the cognitive and neural mechanisms underlying emotional empathy, and how they contribute to the management of patients with impaired emotional empathy.
KW - emotion
KW - empathy
KW - focal lesion studies
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=84897909998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897909998&partnerID=8YFLogxK
U2 - 10.1093/brain/awt317
DO - 10.1093/brain/awt317
M3 - Review article
C2 - 24293265
AN - SCOPUS:84897909998
SN - 0006-8950
VL - 137
SP - 981
EP - 997
JO - Brain
JF - Brain
IS - 4
ER -