Inability of immunohistochemistry to predict clinical outcomes of endometrial cancer patients

Dana R. Gossett, P. Alo, R. E. Bristow, M. Galati, A. Kyshtoobayeva, J. Fruehauf, F. J. Montz

Research output: Contribution to journalArticle

Abstract

Introduction: Despite optimal surgery, some patients with early endometrial carcinoma develop recurrence and die of disease. A number of immunohistochemical (IHC)-identified cell products (markers) have been proposed as predictors of recurrence. This study characterizes a large series of endometrial carcinomas with previously described markers as well as markers that have not been investigated in endometrial carcinoma. Patients and methods: Women who had undergone surgery for endometrial carcinoma were identified and specimens accessed. Tissue blocks were evaluated for ten IHC markers. Results were correlated with last known clinical status. Results: Mean follow-up was 43 months; complete data were available on 117 patients. Two women died of other causes; of the remaining 115, eight died of disease and six were alive with recurrence at last follow-up (12%). Vascular endothelial growth factor staining independently predicted recurrence and death. However, in multivariate analyses, only FIGO stage predicted outcome. Discussion: Our goal was to identify markers to predict which women with endometrial carcinoma were likely to have disease recurrence. We evaluated cell-cycle regulatory proteins, growth factors, hormone receptors, and angiogenic factors, but did not identify any marker that independently predicted outcome in multivariate analysis. This may reflect the few negative outcomes in our population.

Original languageEnglish (US)
Pages (from-to)145-151
Number of pages7
JournalInternational Journal of Gynecological Cancer
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • Endometrial cancer
  • Immunohistochemistry
  • VEGF

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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    Gossett, D. R., Alo, P., Bristow, R. E., Galati, M., Kyshtoobayeva, A., Fruehauf, J., & Montz, F. J. (2004). Inability of immunohistochemistry to predict clinical outcomes of endometrial cancer patients. International Journal of Gynecological Cancer, 14(1), 145-151. https://doi.org/10.1111/j.1048-891x.2004.014028.x