In vivo tracking of cellular therapeutics using magnetic resonance imaging

Christoper M. Long; Jeff W.M. Bulte

doi:10.1517/14712590802715723

In vivo tracking of cellular therapeutics using magnetic resonance imaging

Christoper M. Long, Jeff W.M. Bulte

School of Medicine

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

Background: The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to noninvasively and longitudinally evaluate these parameters for cellular therapy. Objective: To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology. Methods: We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease. Results/conclusion: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.

Original language	English (US)
Pages (from-to)	293-306
Number of pages	14
Journal	Expert Opinion on Biological Therapy
Volume	9
Issue number	3
DOIs	https://doi.org/10.1517/14712590802715723
State	Published - Mar 2009

Keywords

Cell migration
Cell tracking
Contrast agent
Immunotherapy
Magnetic resonance imaging
Stem cells

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Clinical Biochemistry

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abstract = "Background: The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to noninvasively and longitudinally evaluate these parameters for cellular therapy. Objective: To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology. Methods: We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease. Results/conclusion: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.",

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AU - Bulte, Jeff W.M.

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AB - Background: The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to noninvasively and longitudinally evaluate these parameters for cellular therapy. Objective: To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology. Methods: We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease. Results/conclusion: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.

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KW - Contrast agent

KW - Immunotherapy

KW - Magnetic resonance imaging

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In vivo tracking of cellular therapeutics using magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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