In vivo tracking of cellular therapeutics using magnetic resonance imaging

Christoper M. Long, Jeff W.M. Bulte

Research output: Contribution to journalReview article

Abstract

Background: The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to noninvasively and longitudinally evaluate these parameters for cellular therapy. Objective: To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology. Methods: We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease. Results/conclusion: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.

Original languageEnglish (US)
Pages (from-to)293-306
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2009

Keywords

  • Cell migration
  • Cell tracking
  • Contrast agent
  • Immunotherapy
  • Magnetic resonance imaging
  • Stem cells

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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