In vivo three-dimensional MR microscopy of mice with chronic relapsing experimental autoimmune encephalomyelitis after treatment with insulin-like growth factor-I

Su Xu, E. Kay Jordan, Wen Li, Yihong Yang, Scott A. Chesnick, Henry DeF Webster, Stefan Brocke, Laura Quigley, Henry F. McFarland, Joseph A. Frank

Research output: Contribution to journalArticle

Abstract

PURPOSE. The purpose of this study was to determine the ability of three-dimensional in vivo MR microscopy to depict the treatment effects of insulin-like growth factor-I (IGF-I) in SJL mice with chronic relapsing experimental autoimmune encephalomyelitis (crEAE). METHODS: The experiments were performed at 4.7-T on 10 crEAE mice and on one set of control animals. Five crEAE mice were treated with IGF-I and five were treated with a placebo. RESULTS: In the crEAE mice treated with the placebo, in vivo MR microscopy showed areas of abnormal signal throughout the cerebrum, brain stem, and cerebellum. These findings were not present in either the IGF-I-treated mice or the normal control animals. The diffuse alterations in signal intensity in the placebo-treated crEAE mice were not identified on histologic sections of the same areas. CONCLUSION: Differences between the IGF-I- and placebo- treated groups may reflect changes in stabilization or permeability of cell membranes and/or of the blood-brain barrier, although other alternative contrast mechanisms could be playing a role. In vivo MR microscopy depicted changes resulting from treatment of crEAE with IGF-I.

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume19
Issue number4
StatePublished - Apr 1998
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Xu, S., Jordan, E. K., Li, W., Yang, Y., Chesnick, S. A., Webster, H. D., Brocke, S., Quigley, L., McFarland, H. F., & Frank, J. A. (1998). In vivo three-dimensional MR microscopy of mice with chronic relapsing experimental autoimmune encephalomyelitis after treatment with insulin-like growth factor-I. American Journal of Neuroradiology, 19(4), 653-658.