In vivo synthesis of airway-active agents from arachidonic acid

Ernst W Spannhake, J. L. Levin, D. B. McNamara, A. L. Hyman, P. J. Kadowitz

Research output: Contribution to journalArticle

Abstract

Evidence is presented that arachidonic acid can be metabolized, in vivo, to the full spectrum of bronchoactive cyclo-oxygenase products. The predominant activity which results in the healthy lung may vary as a function of several factors, including the quantity and location of available substrate and the pre-existing contractile state of the airways. Production of bronchoactive leukotrienes appears to be minimal in the healthy lung, but the relationship between these two alternative pathways of arachidonic acid metabolism appears to be different in sensitized animals.

Original languageEnglish (US)
Pages (from-to)523-530
Number of pages8
JournalClinical Respiratory Physiology
Volume17
Issue number4
StatePublished - 1981
Externally publishedYes

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Arachidonic Acid
Lung
Leukotrienes
Prostaglandin-Endoperoxide Synthases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Spannhake, E. W., Levin, J. L., McNamara, D. B., Hyman, A. L., & Kadowitz, P. J. (1981). In vivo synthesis of airway-active agents from arachidonic acid. Clinical Respiratory Physiology, 17(4), 523-530.

In vivo synthesis of airway-active agents from arachidonic acid. / Spannhake, Ernst W; Levin, J. L.; McNamara, D. B.; Hyman, A. L.; Kadowitz, P. J.

In: Clinical Respiratory Physiology, Vol. 17, No. 4, 1981, p. 523-530.

Research output: Contribution to journalArticle

Spannhake, EW, Levin, JL, McNamara, DB, Hyman, AL & Kadowitz, PJ 1981, 'In vivo synthesis of airway-active agents from arachidonic acid', Clinical Respiratory Physiology, vol. 17, no. 4, pp. 523-530.
Spannhake EW, Levin JL, McNamara DB, Hyman AL, Kadowitz PJ. In vivo synthesis of airway-active agents from arachidonic acid. Clinical Respiratory Physiology. 1981;17(4):523-530.
Spannhake, Ernst W ; Levin, J. L. ; McNamara, D. B. ; Hyman, A. L. ; Kadowitz, P. J. / In vivo synthesis of airway-active agents from arachidonic acid. In: Clinical Respiratory Physiology. 1981 ; Vol. 17, No. 4. pp. 523-530.
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