Abstract
Evidence is presented that arachidonic acid can be metabolized, in vivo, to the full spectrum of bronchoactive cyclo-oxygenase products. The predominant activity which results in the healthy lung may vary as a function of several factors, including the quantity and location of available substrate and the pre-existing contractile state of the airways. Production of bronchoactive leukotrienes appears to be minimal in the healthy lung, but the relationship between these two alternative pathways of arachidonic acid metabolism appears to be different in sensitized animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 523-530 |
| Number of pages | 8 |
| Journal | Clinical Respiratory Physiology |
| Volume | 17 |
| Issue number | 4 |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
In vivo synthesis of airway-active agents from arachidonic acid. / Spannhake, Ernst W; Levin, J. L.; McNamara, D. B.; Hyman, A. L.; Kadowitz, P. J.
In: Clinical Respiratory Physiology, Vol. 17, No. 4, 1981, p. 523-530.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo synthesis of airway-active agents from arachidonic acid
AU - Spannhake, Ernst W
AU - Levin, J. L.
AU - McNamara, D. B.
AU - Hyman, A. L.
AU - Kadowitz, P. J.
PY - 1981
Y1 - 1981
N2 - Evidence is presented that arachidonic acid can be metabolized, in vivo, to the full spectrum of bronchoactive cyclo-oxygenase products. The predominant activity which results in the healthy lung may vary as a function of several factors, including the quantity and location of available substrate and the pre-existing contractile state of the airways. Production of bronchoactive leukotrienes appears to be minimal in the healthy lung, but the relationship between these two alternative pathways of arachidonic acid metabolism appears to be different in sensitized animals.
AB - Evidence is presented that arachidonic acid can be metabolized, in vivo, to the full spectrum of bronchoactive cyclo-oxygenase products. The predominant activity which results in the healthy lung may vary as a function of several factors, including the quantity and location of available substrate and the pre-existing contractile state of the airways. Production of bronchoactive leukotrienes appears to be minimal in the healthy lung, but the relationship between these two alternative pathways of arachidonic acid metabolism appears to be different in sensitized animals.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019829466&partnerID=8YFLogxK
M3 - Article
C2 - 6120017
AN - SCOPUS:0019829466
VL - 17
SP - 523
EP - 530
JO - Clinical Respiratory Physiology
JF - Clinical Respiratory Physiology
SN - 0272-7587
IS - 4
ER -