In vivo survival of K:18 red cells in a recipient with anti‐K 18

C. Barrasso, H. Drew, P. M. Ness

Research output: Contribution to journalArticlepeer-review

Abstract

Red cell survival, IgG subclass, and mononuclear phagocyte assay studies were performed on a patient with an antl‐K + K18 described previously. The 51Cr survival study with Kell negative K:18 red cells showed 76.6 percent survival at 75 minutes with 30.7 percent survival at 24 hours. The anti‐K18 was characterized as lgG4 + lgG1. The mononuclear phagocyte assay was 16 percent when the serum was tested with K:18 cells. Among 54,450 ABO compatible donor units tested with this serum, no K:18‐ unit was found. These studies were undertaken to evaluate the clinical significance of the antibody when red cell support for a chemotherapy course was considered. Our data suggest that transfusion with K:18+ blood would be ineffective and could be used only to provide red cell support in an emergency should compatible units be unavailable. 1983 AABB

Original languageEnglish (US)
Pages (from-to)258-259
Number of pages2
JournalTransfusion
Volume23
Issue number3
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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