In vivo studies of [125I]iodobenzamide and [11C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D2 dopamine receptors

Dean F. Wong; Alan A. Wilson; Catherine Chen; Elynne Minkin; Robert F. Dannals; Hayden T. Ravert; Patricia Sanchez‐Roa; Victor Villemagne; Henry N. Wagner

doi:10.1002/syn.890120309

In vivo studies of [¹²⁵I]iodobenzamide and [¹¹C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D₂ dopamine receptors

Dean F. Wong, Alan A. Wilson, Catherine Chen, Elynne Minkin, Robert F. Dannals, Hayden T. Ravert, Patricia Sanchez‐Roa, Victor Villemagne, Henry N. Wagner

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Iodobenzamide (IMB) labeled with either [¹¹C] or [¹²⁵I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D₂ dopamine receptors. Mouse biodistribution studies with both [¹¹C]IMB and [¹²⁵I]IMB showed a similar brain distribution of radioactivity. Mouse [¹²⁵I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D₂ receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. © 1992 Wiley‐Liss, Inc.

Original language	English (US)
Pages (from-to)	236-241
Number of pages	6
Journal	Synapse
Volume	12
Issue number	3
DOIs	https://doi.org/10.1002/syn.890120309
State	Published - Nov 1992

Keywords

Endogenous dopamine
In vivo biodistribution
Radioactivity

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

Access to Document

10.1002/syn.890120309

Cite this

Wong, D. F., Wilson, A. A., Chen, C., Minkin, E., Dannals, R. F., Ravert, H. T., Sanchez‐Roa, P., Villemagne, V., & Wagner, H. N. (1992). In vivo studies of [¹²⁵I]iodobenzamide and [¹¹C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D₂ dopamine receptors. Synapse, 12(3), 236-241. https://doi.org/10.1002/syn.890120309

Wong, DF, Wilson, AA, Chen, C, Minkin, E, Dannals, RF, Ravert, HT, Sanchez‐Roa, P, Villemagne, V & Wagner, HN 1992, 'In vivo studies of [¹²⁵I]iodobenzamide and [¹¹C]iodobenzamide: A ligand suitable for positron emission tomography and single photon emission tomography imaging of cerebral D₂ dopamine receptors', Synapse, vol. 12, no. 3, pp. 236-241. https://doi.org/10.1002/syn.890120309

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abstract = "Iodobenzamide (IMB) labeled with either [11C] or [125I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D2 dopamine receptors. Mouse biodistribution studies with both [11C]IMB and [125I]IMB showed a similar brain distribution of radioactivity. Mouse [125I]IMB studies with amphetamine and reserpine pretreatment suggested that IMB may be less susceptible to endogenous dopamine competition for D2 receptor binding in vivo as compared to raclopride. Preliminary baboon studies showed haloperidol competition for IMB binding sites. {\textcopyright} 1992 Wiley‐Liss, Inc.",

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AU - Minkin, Elynne

AU - Dannals, Robert F.

AU - Ravert, Hayden T.

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