In vivo Release of Histamine from Rabbit Blood by Reserpine

T. Phillip Waalkes, Herbert Weissbach

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Intravenous reserpine in rabbits has been demonstrated by chemical means to release histamine from whole blood. 1. The minimal histamine levels were reached in one to 2 days with complete recovery to control values in 5 to 7 days. 2. Simultaneous serotonin determinations, revealed that the rate and degree of liberation, and the recovery of both histamine and serotonin were very similar. 3. Platelets, isolated 24 hours after reserpine, showed a marked reduction in both histamine and serotonin compared to control platelets.

Original languageEnglish (US)
Pages (from-to)394-396
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Nov 1956

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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