In Vivo proton spectroscopy and spectroscopic imaging of {1‐13C}‐g1ucose and its metabolic products

Peter C.M. Van Zijl, A. Scott Chesnick, D. Despres, Chrit T.W. Moonen, J. Rhiz‐Cabello, P. Van Gelderen

Research output: Contribution to journalArticle

Abstract

Metaibolism of {1−13C}‐glucose was studied in situ in cat brain usinig gradient‐enhanced proton‐detected heteronuclear spectroscopy. Proton detection of {1−13C}‐glucose, {3−13C}−lactaite, 4−{13C}‐glutamine, 4−{13C}‐glutamate and the combined signals 2−{13C}‐glutamate/glutamine and 3−(13C}‐glutamate/glutamine was achieved, despite the fact that some of the associated proton resonances are close to the water signal. Two‐dimensional {1H‐13C}‐spectra demonstrate the possibility of in situ spectral assignment with 1H sensitivity and 13C resolution. Spectroscopic images of glucose and its metabolic products were also acquired, showing the possibility to study spatial dependence of metabolism.

Original languageEnglish (US)
Pages (from-to)544-551
Number of pages8
JournalMagnetic resonance in medicine
Volume30
Issue number5
DOIs
StatePublished - Nov 1993

Keywords

  • 2D spectroscopy
  • C‐glucose metabolism
  • proton spectroscopy
  • spectroscopic imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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