In vivo nuclear magnetic resonance chemical shift imaging by selective irradiation

P. A. Bottomley, T. H. Foster, W. M. Leue

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


NMR images of preselected chemically shifted species can be obtained by selective irradiation of the remainder of the NMR chemical shift spectrum prior to application of a conventional NMR imaging sequence. The chemical-selective irradiation consists of narrow-bandwidth π/2 or saturation radio-frequency pulses applied in the absence of imaging gradients. The technique permits substantial reductions in scan and reconstruction times over standard three- and four-dimensional Fourier transform chemical-shift-imaging methods, when images of few spectral peaks are desired. It is also suitable for the elimination of chemical shift artifacts in conventional high-field NMR imaging. In vivo applications of the technique to the head and limbs in a 1.5-T magnetic field yield 1H H2O and -CH2- images, with little detectable -CH2- in muscle and brain.

Original languageEnglish (US)
Pages (from-to)6856-6860
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number21 I
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • General


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