Abstract
OBJECTIVE. The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. CONCLUSION. Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 314-325 |
| Number of pages | 12 |
| Journal | American Journal of Roentgenology |
| Volume | 193 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 2009 |
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Keywords
- Cell tracking
- Immunotherapy
- Molecular imaging
- Stem cell therapy
- Superparamagnetic iron oxide
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
In vivo MRI cell tracking : Clinical studies. / Bulte, Jeff W.
In: American Journal of Roentgenology, Vol. 193, No. 2, 08.2009, p. 314-325.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vivo MRI cell tracking
T2 - Clinical studies
AU - Bulte, Jeff W
PY - 2009/8
Y1 - 2009/8
N2 - OBJECTIVE. The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. CONCLUSION. Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
AB - OBJECTIVE. The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. CONCLUSION. Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.
KW - Cell tracking
KW - Immunotherapy
KW - Molecular imaging
KW - Stem cell therapy
KW - Superparamagnetic iron oxide
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UR - http://www.scopus.com/inward/citedby.url?scp=68149172455&partnerID=8YFLogxK
U2 - 10.2214/AJR.09.3107
DO - 10.2214/AJR.09.3107
M3 - Article
C2 - 19620426
AN - SCOPUS:68149172455
VL - 193
SP - 314
EP - 325
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
SN - 0361-803X
IS - 2
ER -