In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics

Edith V. Sullivan, B. Lane, A. Deshmukh, M. J. Rosenbloom, John Desmond, K. O. Lim, A. Pfefferbaum

Research output: Contribution to journalArticle

Abstract

Background: Neuropathological studies use the presence of mammillary body (MB) pathology as a cardinal, diagnostic feature of Wernicke's encephalopathy (WE) in neuropsychiatric diseases, most notably alcoholism. Although Korsakoff's Syndrome (KS), which is marked behaviorally by dense global amnesia, is a typical sequela of WE, it remains controversial whether these two conditions necessarily co-occur and whether MB pathology is therefore a diagnostic requisite for KS. Methods: We investigated these issues by examining, in vivo, 24 nonamnesic alcoholics (ALC), 5 amnesic alcoholics (KS), and 51 normal controls with three-dimensional MRI and memory testing. MB volume was determined from successive, 1 mm thick slices. Results: The ALC group had significantly smaller MB volumes bilaterally (mean = 54.5 ± 22.0 mm3) than controls (mean = 66.3 ± 17.1 mm3), and the KS group had even smaller MB volumes than the ALC group (mean = 20.7 ± 14.8 mm3). Only 2 ALC patients met historical clinical criteria for past WE, and their MB volumes were well within range of the remaining 22 ALC patients. Although all five KS patients met historical clinical criteria for WE, three KS did not have accompanying dementia and had the same degree of MB volume loss as the ALC; the remaining two KS had accompanying dementia and MB volumes half the volume of the ALC group and of KS patients without dementia. Conclusions: These findings provide volumetric in vivo evidence that: (1) MB volume deficits do occur in alcoholics without amnesia, although these deficits are not present in all such alcoholics; (2) greater MB volume deficits are present in alcoholics with clinically detectable amnesia or dementia; (3) MB shrinkage is related to severity of cognitive and memory dysfunction, which suggests a continuum of MB pathology in chronic alcoholism to KS; and (4) the presence of WE in all of the KS patients and in the two ALC patients with the greatest long-term declarative memory deficit supports the possibility of an additional and unique pathology distinguishing nonamnesic and amnesic alcoholism.

Original languageEnglish (US)
Pages (from-to)1629-1636
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume23
Issue number10
StatePublished - Oct 1999
Externally publishedYes

Fingerprint

Mammillary Bodies
Pathology
Alcoholics
Korsakoff Syndrome
Wernicke Encephalopathy
Data storage equipment
Amnesia
Alcohol Amnestic Disorder
Dementia
Magnetic resonance imaging
Alcoholism
Testing
Long-Term Memory
Memory Disorders

Keywords

  • Alcohol
  • Korsakoff Syndrome
  • Mammillary Body
  • Neuropathology
  • Wernicke's Encephalopathy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Sullivan, E. V., Lane, B., Deshmukh, A., Rosenbloom, M. J., Desmond, J., Lim, K. O., & Pfefferbaum, A. (1999). In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics. Alcoholism: Clinical and Experimental Research, 23(10), 1629-1636.

In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics. / Sullivan, Edith V.; Lane, B.; Deshmukh, A.; Rosenbloom, M. J.; Desmond, John; Lim, K. O.; Pfefferbaum, A.

In: Alcoholism: Clinical and Experimental Research, Vol. 23, No. 10, 10.1999, p. 1629-1636.

Research output: Contribution to journalArticle

Sullivan, EV, Lane, B, Deshmukh, A, Rosenbloom, MJ, Desmond, J, Lim, KO & Pfefferbaum, A 1999, 'In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics', Alcoholism: Clinical and Experimental Research, vol. 23, no. 10, pp. 1629-1636.
Sullivan EV, Lane B, Deshmukh A, Rosenbloom MJ, Desmond J, Lim KO et al. In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics. Alcoholism: Clinical and Experimental Research. 1999 Oct;23(10):1629-1636.
Sullivan, Edith V. ; Lane, B. ; Deshmukh, A. ; Rosenbloom, M. J. ; Desmond, John ; Lim, K. O. ; Pfefferbaum, A. / In vivo mammillary body volume deficits in amnesic and nonamnesic alcoholics. In: Alcoholism: Clinical and Experimental Research. 1999 ; Vol. 23, No. 10. pp. 1629-1636.
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abstract = "Background: Neuropathological studies use the presence of mammillary body (MB) pathology as a cardinal, diagnostic feature of Wernicke's encephalopathy (WE) in neuropsychiatric diseases, most notably alcoholism. Although Korsakoff's Syndrome (KS), which is marked behaviorally by dense global amnesia, is a typical sequela of WE, it remains controversial whether these two conditions necessarily co-occur and whether MB pathology is therefore a diagnostic requisite for KS. Methods: We investigated these issues by examining, in vivo, 24 nonamnesic alcoholics (ALC), 5 amnesic alcoholics (KS), and 51 normal controls with three-dimensional MRI and memory testing. MB volume was determined from successive, 1 mm thick slices. Results: The ALC group had significantly smaller MB volumes bilaterally (mean = 54.5 ± 22.0 mm3) than controls (mean = 66.3 ± 17.1 mm3), and the KS group had even smaller MB volumes than the ALC group (mean = 20.7 ± 14.8 mm3). Only 2 ALC patients met historical clinical criteria for past WE, and their MB volumes were well within range of the remaining 22 ALC patients. Although all five KS patients met historical clinical criteria for WE, three KS did not have accompanying dementia and had the same degree of MB volume loss as the ALC; the remaining two KS had accompanying dementia and MB volumes half the volume of the ALC group and of KS patients without dementia. Conclusions: These findings provide volumetric in vivo evidence that: (1) MB volume deficits do occur in alcoholics without amnesia, although these deficits are not present in all such alcoholics; (2) greater MB volume deficits are present in alcoholics with clinically detectable amnesia or dementia; (3) MB shrinkage is related to severity of cognitive and memory dysfunction, which suggests a continuum of MB pathology in chronic alcoholism to KS; and (4) the presence of WE in all of the KS patients and in the two ALC patients with the greatest long-term declarative memory deficit supports the possibility of an additional and unique pathology distinguishing nonamnesic and amnesic alcoholism.",
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AU - Sullivan, Edith V.

AU - Lane, B.

AU - Deshmukh, A.

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AU - Desmond, John

AU - Lim, K. O.

AU - Pfefferbaum, A.

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N2 - Background: Neuropathological studies use the presence of mammillary body (MB) pathology as a cardinal, diagnostic feature of Wernicke's encephalopathy (WE) in neuropsychiatric diseases, most notably alcoholism. Although Korsakoff's Syndrome (KS), which is marked behaviorally by dense global amnesia, is a typical sequela of WE, it remains controversial whether these two conditions necessarily co-occur and whether MB pathology is therefore a diagnostic requisite for KS. Methods: We investigated these issues by examining, in vivo, 24 nonamnesic alcoholics (ALC), 5 amnesic alcoholics (KS), and 51 normal controls with three-dimensional MRI and memory testing. MB volume was determined from successive, 1 mm thick slices. Results: The ALC group had significantly smaller MB volumes bilaterally (mean = 54.5 ± 22.0 mm3) than controls (mean = 66.3 ± 17.1 mm3), and the KS group had even smaller MB volumes than the ALC group (mean = 20.7 ± 14.8 mm3). Only 2 ALC patients met historical clinical criteria for past WE, and their MB volumes were well within range of the remaining 22 ALC patients. Although all five KS patients met historical clinical criteria for WE, three KS did not have accompanying dementia and had the same degree of MB volume loss as the ALC; the remaining two KS had accompanying dementia and MB volumes half the volume of the ALC group and of KS patients without dementia. Conclusions: These findings provide volumetric in vivo evidence that: (1) MB volume deficits do occur in alcoholics without amnesia, although these deficits are not present in all such alcoholics; (2) greater MB volume deficits are present in alcoholics with clinically detectable amnesia or dementia; (3) MB shrinkage is related to severity of cognitive and memory dysfunction, which suggests a continuum of MB pathology in chronic alcoholism to KS; and (4) the presence of WE in all of the KS patients and in the two ALC patients with the greatest long-term declarative memory deficit supports the possibility of an additional and unique pathology distinguishing nonamnesic and amnesic alcoholism.

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