In vivo magnetic resonance spectroscopy of GABA: A methodological review

Nicolaas Puts; Richard A.E. Edden

doi:10.1016/j.pnmrs.2011.06.001

In vivo magnetic resonance spectroscopy of GABA: A methodological review

Nicolaas Puts, Richard A.E. Edden

School of Medicine

Research output: Contribution to journal › Review article › peer-review

210 Scopus citations

Abstract

A study was conducted to demonstrate a methodological review of in vivo magnetic resonance spectroscopy (MRS) of GABA. Investigations revealed that two main sub-types of GABA receptor, such as GABA _A and GABA _B mediated the synaptic effects of GABA, and synaptic GABA was rapidly removed by high-affinity GABA transporters (GAT). GABA was produced from glutamate by glutamic acid decarboxylase (GAD) within GABAergic neurons and was metabolized to succinic acid semialdehyde by GABA transaminase (GABA-T) and to succinate within astrocytic mitochondria. MRS involved the in vivo application of nuclear magnetic resonance (NMR) spectroscopy and was implemented on magnetic resonance imaging (MRI) scanners. MRS signals were separated in the MR spectrum along chemical lines, known as the chemical shift dimension.

Original language	English (US)
Pages (from-to)	29-41
Number of pages	13
Journal	Progress in Nuclear Magnetic Resonance Spectroscopy
Volume	60
DOIs	https://doi.org/10.1016/j.pnmrs.2011.06.001
State	Published - Jan 2012

Keywords

GABA
Inhibition
J-PRESS
J-difference editing
MRS

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Nuclear and High Energy Physics
Spectroscopy

Access to Document

10.1016/j.pnmrs.2011.06.001

Cite this

@article{3bd4955d58a041e5904607a40f1cdfa9,

title = "In vivo magnetic resonance spectroscopy of GABA: A methodological review",

abstract = "A study was conducted to demonstrate a methodological review of in vivo magnetic resonance spectroscopy (MRS) of GABA. Investigations revealed that two main sub-types of GABA receptor, such as GABA A and GABA B mediated the synaptic effects of GABA, and synaptic GABA was rapidly removed by high-affinity GABA transporters (GAT). GABA was produced from glutamate by glutamic acid decarboxylase (GAD) within GABAergic neurons and was metabolized to succinic acid semialdehyde by GABA transaminase (GABA-T) and to succinate within astrocytic mitochondria. MRS involved the in vivo application of nuclear magnetic resonance (NMR) spectroscopy and was implemented on magnetic resonance imaging (MRI) scanners. MRS signals were separated in the MR spectrum along chemical lines, known as the chemical shift dimension.",

keywords = "GABA, Inhibition, J-PRESS, J-difference editing, MRS",

author = "Nicolaas Puts and Edden, {Richard A.E.}",

note = "Funding Information: This work was supported in part by NIH P41RR015241. ",

year = "2012",

month = jan,

doi = "10.1016/j.pnmrs.2011.06.001",

language = "English (US)",

volume = "60",

pages = "29--41",

journal = "Progress in Nuclear Magnetic Resonance Spectroscopy",

issn = "0079-6565",

publisher = "Elsevier",

}

TY - JOUR

T1 - In vivo magnetic resonance spectroscopy of GABA

T2 - A methodological review

AU - Puts, Nicolaas

AU - Edden, Richard A.E.

N1 - Funding Information: This work was supported in part by NIH P41RR015241.

PY - 2012/1

Y1 - 2012/1

N2 - A study was conducted to demonstrate a methodological review of in vivo magnetic resonance spectroscopy (MRS) of GABA. Investigations revealed that two main sub-types of GABA receptor, such as GABA A and GABA B mediated the synaptic effects of GABA, and synaptic GABA was rapidly removed by high-affinity GABA transporters (GAT). GABA was produced from glutamate by glutamic acid decarboxylase (GAD) within GABAergic neurons and was metabolized to succinic acid semialdehyde by GABA transaminase (GABA-T) and to succinate within astrocytic mitochondria. MRS involved the in vivo application of nuclear magnetic resonance (NMR) spectroscopy and was implemented on magnetic resonance imaging (MRI) scanners. MRS signals were separated in the MR spectrum along chemical lines, known as the chemical shift dimension.

AB - A study was conducted to demonstrate a methodological review of in vivo magnetic resonance spectroscopy (MRS) of GABA. Investigations revealed that two main sub-types of GABA receptor, such as GABA A and GABA B mediated the synaptic effects of GABA, and synaptic GABA was rapidly removed by high-affinity GABA transporters (GAT). GABA was produced from glutamate by glutamic acid decarboxylase (GAD) within GABAergic neurons and was metabolized to succinic acid semialdehyde by GABA transaminase (GABA-T) and to succinate within astrocytic mitochondria. MRS involved the in vivo application of nuclear magnetic resonance (NMR) spectroscopy and was implemented on magnetic resonance imaging (MRI) scanners. MRS signals were separated in the MR spectrum along chemical lines, known as the chemical shift dimension.

KW - GABA

KW - Inhibition

KW - J-PRESS

KW - J-difference editing

KW - MRS

UR - http://www.scopus.com/inward/record.url?scp=81255175422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81255175422&partnerID=8YFLogxK

U2 - 10.1016/j.pnmrs.2011.06.001

DO - 10.1016/j.pnmrs.2011.06.001

M3 - Review article

C2 - 22293397

AN - SCOPUS:81255175422

SN - 0079-6565

VL - 60

SP - 29

EP - 41

JO - Progress in Nuclear Magnetic Resonance Spectroscopy

JF - Progress in Nuclear Magnetic Resonance Spectroscopy

ER -

In vivo magnetic resonance spectroscopy of GABA: A methodological review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this