@article{ac9dcf0a717549598ab31ce35e7b425a,
title = "In vivo imaging of CNS injury and disease",
abstract = "In vivo optical imaging has emerged as a powerful tool with which to study cellular responses to injury and disease in the mammalian CNS. Important new insights have emerged regarding axonal degeneration and regeneration, glial responses and neuro inflammation, changes in the neurovascular unit, and, more recently, neural transplantations. Accompanying a 2017 SfN Mini-Symposium, here, we discuss selected recent advances in understanding the neuronal, glial, and other cellular responses to CNS injury and disease with in vivo imaging of the rodent brain or spinal cord. We anticipate that in vivo optical imaging will continue to be at the forefront of breakthrough discoveries of fundamental mechanisms and therapies for CNS injury and disease.",
keywords = "Blood-brain barrier, IPSCs, Microglia, Retina, Two-photon imaging",
author = "Katerina Akassoglou and Mario Merlini and Rafalski, {Victoria A.} and Raquel Real and Liang Liang and Yunju Jin and Dougherty, {Sarah E.} and {De Paola}, Vincenzo and Linden, {David J.} and Thomas Misgeld and Binhai Zheng",
note = "Funding Information: ThisworkwassupportedbytheNationalInstitutesofHealth(GrantNS097976toK.A.;GrantNS096920toV.A.R.; Grants NS081467, MH100024, NS095907, and NS095879 to D.J.L.; Grants NS093055, NS054734 to B.Z., and NS047101 to the UCSD Neuroscience Microscopy P30 Center), the National MS Society (Grant RG4985A3), the DepartmentofDefense(GrantMS160082),theConradN.HiltonFoundation(K.A.),theMedicalResearchCouncilUK (V.D.P.), Alzheimer{\textquoteright}s Research UK (V.D.P.), Portuguese funding agency for science, research and technology and Rosetrees Trust (R.R. and V.D.P.), the Simons Foundation (L.L.), the Harvard/Massachusetts Institute of Technology JointResearchGrantsPrograminBasicNeuroscience(C.C.andM.L.A.),theGermanResearchFoundation(EXC1010, EXC114, SFB870, Mi694/7-1 and 8-1 to T.M.), the European Research Council (FP/2007-2013, 616791 to T.M.), and the Dana Foundation (B.Z.). L.L. thanks Chinfei Chen and Mark L. Andermann for mentorship and support. The authors declare no competing financial interests. *K.A., L.L., V.D.P., D.J.L., T.M., and B.Z. contributed equally to this work. Publisher Copyright: {\textcopyright} 2017 the authors.",
year = "2017",
month = nov,
day = "8",
doi = "10.1523/JNEUROSCI.1826-17.2017",
language = "English (US)",
volume = "37",
pages = "10808--10816",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "45",
}