In vivo hysteresis of airspace dimensions measured by aerosol recovery

William D. Bennett, Wayne A Mitzner

Research output: Contribution to journalArticle

Abstract

In anesthetized mongrel dogs, we made measurements of single breath aerosol recovery (RC) at equal volume points on the inflation and deflation limb of the quasi-static pressure-volume (P-V) curve of the lungs. Using a 1.2 μm monodisperse aerosol, a large aerosol tidal volume (Vt), and a breathing period of 5 sec, we found that losses of particles were primarily due to sedimentation in pulmonary airspaces distal to anatomic dead space. Thus, the RC measurements could be related to a mean radius (R) of airspaces filled with aerosol over the course of the breath. Furthermore, at a given volume, differences between inflation and deflation limb RC could be attributed to differences in R for the two measurements (i.e., Ri vs Rd). We found that at isovolume, RC as measured from the inflation limb was larger than that measured from the deflation limb for low lung volumes (0.75 TLC). These results implied that at the same volume, Ri>Rdexcept at volumes approaching TLC, i.e. a larger mean airspace dimension on the inflation limb than on the deflation limb at equal volume. The findings of this study support a model of nonuniform changes in airspace dimensions associated with in vivo inflation and deflation of the lungs.

Original languageEnglish (US)
Pages (from-to)85-99
Number of pages15
JournalRespiration Physiology
Volume67
Issue number1
DOIs
StatePublished - 1987

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Aerosols
Economic Inflation
Extremities
Lung
Tidal Volume
Respiration
Dogs
Pressure

Keywords

  • Aerosol recovery
  • Airspace hysteresis
  • Dog
  • Monodisperse aerosols

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

In vivo hysteresis of airspace dimensions measured by aerosol recovery. / Bennett, William D.; Mitzner, Wayne A.

In: Respiration Physiology, Vol. 67, No. 1, 1987, p. 85-99.

Research output: Contribution to journalArticle

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