In vivo high resolution human corneal imaging using full-field optical coherence tomography

Viacheslav Mazlin, Peng Xiao, Eugénie Dalimier, Kate Grieve, Kristina Irsch, José Alain Sahel, Mathias Fink, A. Claude Boccara

Research output: Contribution to journalArticle

Abstract

We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowman’s layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet’s membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 µm and relatively large field-of-view of 1.26 mm x 1.26 mm – a combination, which, to the best of our knowledge, has not been possible with other in vivo human eye imaging methods. The latter together with a contactless operation, make FFOCT a promising candidate for becoming a new tool in ophthalmic diagnostics.

Original languageEnglish (US)
Article number#312708
Pages (from-to)557-568
Number of pages12
JournalBiomedical Optics Express
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Optical Coherence Tomography
nerves
tomography
Descemet Membrane
cornea
high resolution
Cornea
field of view
Endothelial Cells
membranes
Equipment and Supplies
nuclei

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Mazlin, V., Xiao, P., Dalimier, E., Grieve, K., Irsch, K., Sahel, J. A., ... Boccara, A. C. (2018). In vivo high resolution human corneal imaging using full-field optical coherence tomography. Biomedical Optics Express, 9(2), 557-568. [#312708]. https://doi.org/10.1364/BOE.9.000557

In vivo high resolution human corneal imaging using full-field optical coherence tomography. / Mazlin, Viacheslav; Xiao, Peng; Dalimier, Eugénie; Grieve, Kate; Irsch, Kristina; Sahel, José Alain; Fink, Mathias; Boccara, A. Claude.

In: Biomedical Optics Express, Vol. 9, No. 2, #312708, 01.02.2018, p. 557-568.

Research output: Contribution to journalArticle

Mazlin, V, Xiao, P, Dalimier, E, Grieve, K, Irsch, K, Sahel, JA, Fink, M & Boccara, AC 2018, 'In vivo high resolution human corneal imaging using full-field optical coherence tomography', Biomedical Optics Express, vol. 9, no. 2, #312708, pp. 557-568. https://doi.org/10.1364/BOE.9.000557
Mazlin, Viacheslav ; Xiao, Peng ; Dalimier, Eugénie ; Grieve, Kate ; Irsch, Kristina ; Sahel, José Alain ; Fink, Mathias ; Boccara, A. Claude. / In vivo high resolution human corneal imaging using full-field optical coherence tomography. In: Biomedical Optics Express. 2018 ; Vol. 9, No. 2. pp. 557-568.
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