In vivo high resolution human corneal imaging using full-field optical coherence tomography

Viacheslav Mazlin, Peng Xiao, Eugénie Dalimier, Kate Grieve, Kristina Irsch, José Alain Sahel, Mathias Fink, A. Claude Boccara

Research output: Contribution to journalArticlepeer-review

Abstract

We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowman’s layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet’s membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 µm and relatively large field-of-view of 1.26 mm x 1.26 mm – a combination, which, to the best of our knowledge, has not been possible with other in vivo human eye imaging methods. The latter together with a contactless operation, make FFOCT a promising candidate for becoming a new tool in ophthalmic diagnostics.

Original languageEnglish (US)
Article number#312708
Pages (from-to)557-568
Number of pages12
JournalBiomedical Optics Express
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2018

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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