In vivo functions of Drp1: Lessons learned from yeast genetics and mouse knockouts

Hiromi Sesaki, Yoshihiro Adachi, Yusuke Kageyama, Kie Itoh, Miho Iijima

Research output: Contribution to journalReview article

Abstract

Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress inmitochondrial division by focusing on molecular and invivo analyses of the evolutionarily conserved, centralcomponent of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases.

Original languageEnglish (US)
Pages (from-to)1179-1185
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1842
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Dynamin-related GTPase
  • Membrane fission
  • Mitochondrion
  • Mouse
  • Neurodegeneration
  • Yeast

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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