TY - JOUR
T1 - In vivo functions of Drp1
T2 - Lessons learned from yeast genetics and mouse knockouts
AU - Sesaki, Hiromi
AU - Adachi, Yoshihiro
AU - Kageyama, Yusuke
AU - Itoh, Kie
AU - Iijima, Miho
N1 - Funding Information:
We thank many scientists who advanced our understanding of mitochondrial dynamics, and apologize that we were unable to cite all of the relevant research due to space restrictions. This work was supported by NIH grants to M.I. ( GM084015 ) and H.S. ( GM089853 and NS084154 ).
PY - 2014/8
Y1 - 2014/8
N2 - Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress inmitochondrial division by focusing on molecular and invivo analyses of the evolutionarily conserved, centralcomponent of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases.
AB - Mitochondria grow, divide, and fuse in cells. Mitochondrial division is critical for the maintenance of the structure and function of mitochondria. Alterations in this process have been linked to many human diseases, including peripheral neuropathies and aging-related neurological disorders. In this review, we discuss recent progress inmitochondrial division by focusing on molecular and invivo analyses of the evolutionarily conserved, centralcomponent of mitochondrial division, dynamin-related protein 1 (Drp1), in the yeast and mouse model organisms. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases.
KW - Dynamin-related GTPase
KW - Membrane fission
KW - Mitochondrion
KW - Mouse
KW - Neurodegeneration
KW - Yeast
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U2 - 10.1016/j.bbadis.2013.11.024
DO - 10.1016/j.bbadis.2013.11.024
M3 - Review article
C2 - 24326103
AN - SCOPUS:84903268566
SN - 0925-4439
VL - 1842
SP - 1179
EP - 1185
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 8
ER -