In vivo distribution of some 17-hydroxycorticosteroids between the plasma and red blood cells of man

Claude J. Migeon, Betty Lawrence, Jean Bertrand, Gerald H. Holman

Research output: Contribution to journalArticle

Abstract

Various corticosteroids (cortisol, tetrahydrocortisol or tetrahydrocortisone intravenously, 1 mg. per Kg. of body weight; 4-C14-cortisol intravenously, 1 microcurie; cortisol or cortisone acetate orally, 100 mg.) were administered to normal adult subjects. Blood samples were obtained at specific intervals following administration of steroid. 17-Hydroxycorticosteroid (17-OH-CS) extracts of red cells and plasma were prepared. In all cases, a significant fraction of the free 17-OH-CS of the various blood samples was associated with the red cells (average, 25.1 per cent; range, 17.7 to 36.5 per cent), whereas the total amount of the 17-OH-CS glucuronides was found in the plasma.

Original languageEnglish (US)
Pages (from-to)1411-1419
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume19
Issue number11
DOIs
StatePublished - 1959

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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