In vivo distribution of some 17-hydroxycorticosteroids between the plasma and red blood cells of man

Claude J. Migeon; Betty Lawrence; Jean Bertrand; Gerald H. Holman

doi:10.1210/jcem-19-11-1411

In vivo distribution of some 17-hydroxycorticosteroids between the plasma and red blood cells of man

Claude J. Migeon, Betty Lawrence, Jean Bertrand, Gerald H. Holman

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Various corticosteroids (cortisol, tetrahydrocortisol or tetrahydrocortisone intravenously, 1 mg. per Kg. of body weight; 4-C¹⁴-cortisol intravenously, 1 microcurie; cortisol or cortisone acetate orally, 100 mg.) were administered to normal adult subjects. Blood samples were obtained at specific intervals following administration of steroid. 17-Hydroxycorticosteroid (17-OH-CS) extracts of red cells and plasma were prepared. In all cases, a significant fraction of the free 17-OH-CS of the various blood samples was associated with the red cells (average, 25.1 per cent; range, 17.7 to 36.5 per cent), whereas the total amount of the 17-OH-CS glucuronides was found in the plasma.

Original language	English (US)
Pages (from-to)	1411-1419
Number of pages	9
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	19
Issue number	11
DOIs	https://doi.org/10.1210/jcem-19-11-1411
State	Published - Nov 1959
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-19-11-1411

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title = "In vivo distribution of some 17-hydroxycorticosteroids between the plasma and red blood cells of man",

abstract = "Various corticosteroids (cortisol, tetrahydrocortisol or tetrahydrocortisone intravenously, 1 mg. per Kg. of body weight; 4-C14-cortisol intravenously, 1 microcurie; cortisol or cortisone acetate orally, 100 mg.) were administered to normal adult subjects. Blood samples were obtained at specific intervals following administration of steroid. 17-Hydroxycorticosteroid (17-OH-CS) extracts of red cells and plasma were prepared. In all cases, a significant fraction of the free 17-OH-CS of the various blood samples was associated with the red cells (average, 25.1 per cent; range, 17.7 to 36.5 per cent), whereas the total amount of the 17-OH-CS glucuronides was found in the plasma.",

author = "Migeon, {Claude J.} and Betty Lawrence and Jean Bertrand and Holman, {Gerald H.}",

year = "1959",

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journal = "Journal of Clinical Endocrinology and Metabolism",

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T1 - In vivo distribution of some 17-hydroxycorticosteroids between the plasma and red blood cells of man

AU - Migeon, Claude J.

AU - Lawrence, Betty

AU - Bertrand, Jean

AU - Holman, Gerald H.

PY - 1959/11

Y1 - 1959/11

N2 - Various corticosteroids (cortisol, tetrahydrocortisol or tetrahydrocortisone intravenously, 1 mg. per Kg. of body weight; 4-C14-cortisol intravenously, 1 microcurie; cortisol or cortisone acetate orally, 100 mg.) were administered to normal adult subjects. Blood samples were obtained at specific intervals following administration of steroid. 17-Hydroxycorticosteroid (17-OH-CS) extracts of red cells and plasma were prepared. In all cases, a significant fraction of the free 17-OH-CS of the various blood samples was associated with the red cells (average, 25.1 per cent; range, 17.7 to 36.5 per cent), whereas the total amount of the 17-OH-CS glucuronides was found in the plasma.

AB - Various corticosteroids (cortisol, tetrahydrocortisol or tetrahydrocortisone intravenously, 1 mg. per Kg. of body weight; 4-C14-cortisol intravenously, 1 microcurie; cortisol or cortisone acetate orally, 100 mg.) were administered to normal adult subjects. Blood samples were obtained at specific intervals following administration of steroid. 17-Hydroxycorticosteroid (17-OH-CS) extracts of red cells and plasma were prepared. In all cases, a significant fraction of the free 17-OH-CS of the various blood samples was associated with the red cells (average, 25.1 per cent; range, 17.7 to 36.5 per cent), whereas the total amount of the 17-OH-CS glucuronides was found in the plasma.

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JF - Journal of Clinical Endocrinology and Metabolism

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In vivo distribution of some 17-hydroxycorticosteroids between the plasma and red blood cells of man

Abstract

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