In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla

Richard A.E. Edden; Martin G. Pomper; Peter B. Barker

doi:10.1002/mrm.21234

In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla

Richard A.E. Edden, Martin G. Pomper, Peter B. Barker

School of Medicine

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

A method is described that allows the in vivo differentiation of N-acetyl aspartate (NAA) from N-acetyl aspartyl glutamate (NAAG) by in vivo MR spectroscopy (MRS) at 3 Tesla (3T). The method, which is based on MEGA-point-resolved spectroscopy (PRESS) editing, selectively targets the aspartyl spin system of one species while deliberately removing the other species from the spectrum. This allows quantitative measurements of NAA and NAAG without the need for fitting of unresolved peaks. White matter concentrations of NAA (6.7 ± 0.3 mM) and NAAG (2.2 ± 0.3 mM) were measured in 10 healthy volunteers to demonstrate the method.

Original language	English (US)
Pages (from-to)	977-982
Number of pages	6
Journal	Magnetic resonance in medicine
Volume	57
Issue number	6
DOIs	https://doi.org/10.1002/mrm.21234
State	Published - Jun 2007

Keywords

3 Tesla
MEGA-PRESS
Magnetic resonance spectroscopy
NAA
NAAG

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.21234

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abstract = "A method is described that allows the in vivo differentiation of N-acetyl aspartate (NAA) from N-acetyl aspartyl glutamate (NAAG) by in vivo MR spectroscopy (MRS) at 3 Tesla (3T). The method, which is based on MEGA-point-resolved spectroscopy (PRESS) editing, selectively targets the aspartyl spin system of one species while deliberately removing the other species from the spectrum. This allows quantitative measurements of NAA and NAAG without the need for fitting of unresolved peaks. White matter concentrations of NAA (6.7 ± 0.3 mM) and NAAG (2.2 ± 0.3 mM) were measured in 10 healthy volunteers to demonstrate the method.",

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In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla

Abstract

Keywords

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