In vivo demonstration of inflammatory mediator release following nasal challenge with antigen.

R. M. Naclerio, H. L. Meier, N Franklin Adkinson, A. Kagey-Sobotka, D. A. Meyers, Philip S. Norman, L. M. Lichtenstein

Research output: Contribution to journalArticle

Abstract

An in vivo model system was developed to recover inflammatory mediators from the nose after antigen stimulation. In 105 experiments involving 35 subjects, antigen was introduced into the nose. Allergic individuals demonstrated an increase concentration of histamine, TAMe esterase and PgD2 during the physiologic changes of nasal obstruction and sneezing. Clinical symptoms and mediator release were highly correlated; moreover, the release of each mediator was significantly correlated to the others.

Original languageEnglish (US)
JournalEuropean journal of respiratory diseases. Supplement
Volume128
StatePublished - 1983
Externally publishedYes

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Nose
Sneezing
Antigens
Nasal Obstruction
Esterases
Histamine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

In vivo demonstration of inflammatory mediator release following nasal challenge with antigen. / Naclerio, R. M.; Meier, H. L.; Adkinson, N Franklin; Kagey-Sobotka, A.; Meyers, D. A.; Norman, Philip S.; Lichtenstein, L. M.

In: European journal of respiratory diseases. Supplement, Vol. 128, 1983.

Research output: Contribution to journalArticle

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AU - Meyers, D. A.

AU - Norman, Philip S.

AU - Lichtenstein, L. M.

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