In vivo demonstration of inflammatory mediator release following nasal challenge with antigen.

R. M. Naclerio; H. L. Meier; N. F. Adkinson; A. Kagey-Sobotka; D. A. Meyers; P. S. Norman; L. M. Lichtenstein

In vivo demonstration of inflammatory mediator release following nasal challenge with antigen.

R. M. Naclerio, H. L. Meier, N. F. Adkinson, A. Kagey-Sobotka, D. A. Meyers, P. S. Norman, L. M. Lichtenstein

Research output: Contribution to journal › Article › peer-review

Abstract

An in vivo model system was developed to recover inflammatory mediators from the nose after antigen stimulation. In 105 experiments involving 35 subjects, antigen was introduced into the nose. Allergic individuals demonstrated an increase concentration of histamine, TAMe esterase and PgD2 during the physiologic changes of nasal obstruction and sneezing. Clinical symptoms and mediator release were highly correlated; moreover, the release of each mediator was significantly correlated to the others.

Original language	English (US)
Pages (from-to)	Pt 1/-
Journal	European journal of respiratory diseases. Supplement
Volume	128
State	Published - Jan 1 1983
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "In vivo demonstration of inflammatory mediator release following nasal challenge with antigen.",

abstract = "An in vivo model system was developed to recover inflammatory mediators from the nose after antigen stimulation. In 105 experiments involving 35 subjects, antigen was introduced into the nose. Allergic individuals demonstrated an increase concentration of histamine, TAMe esterase and PgD2 during the physiologic changes of nasal obstruction and sneezing. Clinical symptoms and mediator release were highly correlated; moreover, the release of each mediator was significantly correlated to the others.",

author = "Naclerio, {R. M.} and Meier, {H. L.} and Adkinson, {N. F.} and A. Kagey-Sobotka and Meyers, {D. A.} and Norman, {P. S.} and Lichtenstein, {L. M.}",

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AU - Meier, H. L.

AU - Adkinson, N. F.

AU - Kagey-Sobotka, A.

AU - Meyers, D. A.

AU - Norman, P. S.

AU - Lichtenstein, L. M.

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N2 - An in vivo model system was developed to recover inflammatory mediators from the nose after antigen stimulation. In 105 experiments involving 35 subjects, antigen was introduced into the nose. Allergic individuals demonstrated an increase concentration of histamine, TAMe esterase and PgD2 during the physiologic changes of nasal obstruction and sneezing. Clinical symptoms and mediator release were highly correlated; moreover, the release of each mediator was significantly correlated to the others.

AB - An in vivo model system was developed to recover inflammatory mediators from the nose after antigen stimulation. In 105 experiments involving 35 subjects, antigen was introduced into the nose. Allergic individuals demonstrated an increase concentration of histamine, TAMe esterase and PgD2 during the physiologic changes of nasal obstruction and sneezing. Clinical symptoms and mediator release were highly correlated; moreover, the release of each mediator was significantly correlated to the others.

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ER -

In vivo demonstration of inflammatory mediator release following nasal challenge with antigen.

Abstract

ASJC Scopus subject areas

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