In vivo delivery of BCNU from a MEMS device to a tumor model

Yawen Li, Hong Linh Ho Duc, Betty Mae Tyler, Tiffany Williams, Malinda Tupper, Robert Langer, Henry Brem, Michael J. Cima

Research output: Contribution to journalArticle

Abstract

A drug delivery micrcoelectromechanical systems (MEMS) device was used to locally deliver a chemotherapeutic agent (BCNU) to an experimental tumor in rats. This MEMS device consists of an array of reservoirs etched into the silicon substrate. The drug release is achieved by the electrochemical dissolution of the gold membranes covering the reservoirs. A new Pyrex package was developed to improve the BCNU release kinetics and enhance device capacity. Co-formulation of BCNU with polyethylene glycol (PEG) led to complete and rapid release of drug in vivo. BCNU delivered from the MEMS device showed dose-dependent inhibiting effect on the tumor growth in the BCNU dosage range of 0.67∼2 mg. BCNU delivered from the activated devices was as effective as equipotent subcutaneous injections of BCNU in inhibiting tumor growth. Further optimization using this MEMS device to deliver BCNU in combination with other therapeutic agents against the tumor challenge is possible because of the unique capability of the device to precisely control the temporal release profiles of multiple substances.

Original languageEnglish (US)
Pages (from-to)138-145
Number of pages8
JournalJournal of Controlled Release
Volume106
Issue number1-2
DOIs
StatePublished - Aug 18 2005

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Carmustine
Equipment and Supplies
Neoplasms
Silicon
Subcutaneous Injections
Drug Delivery Systems
Growth
Gold
Membranes

Keywords

  • BCNU
  • Drug delivery
  • Microelectromechanical systems (MEMS)
  • Release kinetics
  • Tumor

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Li, Y., Duc, H. L. H., Tyler, B. M., Williams, T., Tupper, M., Langer, R., ... Cima, M. J. (2005). In vivo delivery of BCNU from a MEMS device to a tumor model. Journal of Controlled Release, 106(1-2), 138-145. https://doi.org/10.1016/j.jconrel.2005.04.009

In vivo delivery of BCNU from a MEMS device to a tumor model. / Li, Yawen; Duc, Hong Linh Ho; Tyler, Betty Mae; Williams, Tiffany; Tupper, Malinda; Langer, Robert; Brem, Henry; Cima, Michael J.

In: Journal of Controlled Release, Vol. 106, No. 1-2, 18.08.2005, p. 138-145.

Research output: Contribution to journalArticle

Li, Y, Duc, HLH, Tyler, BM, Williams, T, Tupper, M, Langer, R, Brem, H & Cima, MJ 2005, 'In vivo delivery of BCNU from a MEMS device to a tumor model', Journal of Controlled Release, vol. 106, no. 1-2, pp. 138-145. https://doi.org/10.1016/j.jconrel.2005.04.009
Li, Yawen ; Duc, Hong Linh Ho ; Tyler, Betty Mae ; Williams, Tiffany ; Tupper, Malinda ; Langer, Robert ; Brem, Henry ; Cima, Michael J. / In vivo delivery of BCNU from a MEMS device to a tumor model. In: Journal of Controlled Release. 2005 ; Vol. 106, No. 1-2. pp. 138-145.
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