In vivo blood T1 measurements at 1.5 T, 3 T, and 7 T

X. Zhang, E. T. Petersen, E. Ghariq, J. B. De Vis, A. G. Webb, W. M. Teeuwisse, J. Hendrikse, M. J.P. Van Osch

Research output: Contribution to journalArticlepeer-review


The longitudinal relaxation time of blood is a crucial parameter for quantification of cerebral blood flow by arterial spin labeling and is one of the main determinants of the signal-to-noise ratio of the resulting perfusion maps. Whereas at low and medium magnetic field strengths (B0), its in vivo value is well established; at ultra-high field, this is still uncertain. In this study, longitudinal relaxation time of blood in the sagittal sinus was measured at 1.5 T, 3 T, and 7 T. A nonselective inversion pulse preceding a Look-Locker echo planar imaging sequence was performed to obtain the inversion recovery curve of venous blood. The results showed that longitudinal relaxation time of blood at 7 T was ∼ 2.1 s which translates to an anticipated 33% gain in the signal-to-noise ratio in arterial spin labeling experiments due to T1 relaxation alone compared with 3 T. In addition, the linear relationship between longitudinal relaxation time of blood and B0 was confirmed.

Original languageEnglish (US)
Pages (from-to)1082-1086
Number of pages5
JournalMagnetic resonance in medicine
Issue number4
StatePublished - Oct 2013


  • 7 T
  • arterial spin labeling
  • longitudinal relaxation time
  • magnetic field

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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