In vivo biodistribution of dendrimers and dendrimer nanocomposites - Implications for cancer imaging and therapy

Mohamed K. Khan, Shraddha S. Nigavekar, Leah D. Minc, Muhammed S.T. Kariapper, Bindu M. Nair, Wojciech G. Lesniak, Lajos P. Balogh

Research output: Contribution to journalReview article

Abstract

Our results indicate that the surface chemistry, composition, and 3-D structure of nanoparticles are critical in determining their in vivo biodistribution, and therefore the efficacy of nanodevice imaging and therapies. We demonstrate that gold/dendrimer nanocomposites in vivo, present biodistribution characteristics different from PAMAM dendrimers in a B16 mouse tumor model system. We review important chemical and biologic uses of these nanodevices and discuss the potential of nanocomposite devices to greatly improve cancer imaging and therapy, in particular radiation therapy. We also discuss major issues confronting the use of nanoparticles in the near future, with consideration of toxicity analysis and whether biodegradable devices are needed or even desirable.

Original languageEnglish (US)
Pages (from-to)603-613
Number of pages11
JournalTechnology in Cancer Research and Treatment
Volume4
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Keywords

  • And Toxicity
  • Biodegradable device
  • Cancer
  • Gold/dendrimer nanocomposite
  • Guest-Host nanodevices
  • Imaging
  • Nanoparticle
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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