The regional distribution of N1′-(11C]methyl)naltrindole ([11C]MeNTI) in vivo in mouse brain correlates with established δ opioid receptor densities in vitro. [11C]MeNTI binding is blocked by naltrindole, a δ antagonist, but not by cyprodime, a μ antagonist, of by (±)-U50,488, a κ agonist. Thus, [11C]MeNTI selectively labels central δ opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of δ sites in human brain.
- Opioid receptors
- PET (positron emmission tomography)
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