In vivo binding of N1′-([11C]methyl)naltrindole to δ-opioid receptors in mouse brain

John R. Lever; Ursula Scheffel; Christopher M. Kinter; Hayden T. Ravert; Robert F. Dannals; Henry N. Wagner; J. James Frost

doi:10.1016/0014-2999(92)90448-D

In vivo binding of N1′-([¹¹C]methyl)naltrindole to δ-opioid receptors in mouse brain

John R. Lever, Ursula Scheffel, Christopher M. Kinter, Hayden T. Ravert, Robert F. Dannals, Henry N. Wagner, J. James Frost

School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The regional distribution of N1′-(¹¹C]methyl)naltrindole ([¹¹C]MeNTI) in vivo in mouse brain correlates with established δ opioid receptor densities in vitro. [¹¹C]MeNTI binding is blocked by naltrindole, a δ antagonist, but not by cyprodime, a μ antagonist, of by (±)-U50,488, a κ agonist. Thus, [¹¹C]MeNTI selectively labels central δ opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of δ sites in human brain.

Original language	English (US)
Pages (from-to)	459-460
Number of pages	2
Journal	European Journal of Pharmacology
Volume	216
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(92)90448-D
State	Published - Jun 17 1992

Keywords

Naltrindole
Opioid receptors
PET (positron emmission tomography)
δ

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(92)90448-D

Cite this

@article{ebcef0765fd4440d858a9a2660df77b5,

title = "In vivo binding of N1′-([11C]methyl)naltrindole to δ-opioid receptors in mouse brain",

abstract = "The regional distribution of N1′-(11C]methyl)naltrindole ([11C]MeNTI) in vivo in mouse brain correlates with established δ opioid receptor densities in vitro. [11C]MeNTI binding is blocked by naltrindole, a δ antagonist, but not by cyprodime, a μ antagonist, of by (±)-U50,488, a κ agonist. Thus, [11C]MeNTI selectively labels central δ opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of δ sites in human brain.",

keywords = "Naltrindole, Opioid receptors, PET (positron emmission tomography), δ",

author = "Lever, {John R.} and Ursula Scheffel and Kinter, {Christopher M.} and Ravert, {Hayden T.} and Dannals, {Robert F.} and Wagner, {Henry N.} and Frost, {J. James}",

note = "Funding Information: This research was supported by NINDS Grant NS-15080 and by a postdoctoral fellowship (CMK) through NCI Training Grant CA-09199. The authors thank John Flesher, Christine Steinert, Marigo Stathis and Robert Smoot for excellent technical assistance.",

year = "1992",

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doi = "10.1016/0014-2999(92)90448-D",

language = "English (US)",

volume = "216",

pages = "459--460",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

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T1 - In vivo binding of N1′-([11C]methyl)naltrindole to δ-opioid receptors in mouse brain

AU - Lever, John R.

AU - Scheffel, Ursula

AU - Kinter, Christopher M.

AU - Ravert, Hayden T.

AU - Dannals, Robert F.

AU - Wagner, Henry N.

AU - Frost, J. James

N1 - Funding Information: This research was supported by NINDS Grant NS-15080 and by a postdoctoral fellowship (CMK) through NCI Training Grant CA-09199. The authors thank John Flesher, Christine Steinert, Marigo Stathis and Robert Smoot for excellent technical assistance.

PY - 1992/6/17

Y1 - 1992/6/17

N2 - The regional distribution of N1′-(11C]methyl)naltrindole ([11C]MeNTI) in vivo in mouse brain correlates with established δ opioid receptor densities in vitro. [11C]MeNTI binding is blocked by naltrindole, a δ antagonist, but not by cyprodime, a μ antagonist, of by (±)-U50,488, a κ agonist. Thus, [11C]MeNTI selectively labels central δ opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of δ sites in human brain.

AB - The regional distribution of N1′-(11C]methyl)naltrindole ([11C]MeNTI) in vivo in mouse brain correlates with established δ opioid receptor densities in vitro. [11C]MeNTI binding is blocked by naltrindole, a δ antagonist, but not by cyprodime, a μ antagonist, of by (±)-U50,488, a κ agonist. Thus, [11C]MeNTI selectively labels central δ opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of δ sites in human brain.

KW - Naltrindole

KW - Opioid receptors

KW - PET (positron emmission tomography)

KW - δ

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