In vivo binding of N1′-([11C]methyl)naltrindole to δ-opioid receptors in mouse brain

John R. Lever, Ursula Scheffel, Christopher M. Kinter, Hayden T. Ravert, Robert F. Dannals, Henry N. Wagner, J. James Frost

Research output: Contribution to journalArticlepeer-review

Abstract

The regional distribution of N1′-(11C]methyl)naltrindole ([11C]MeNTI) in vivo in mouse brain correlates with established δ opioid receptor densities in vitro. [11C]MeNTI binding is blocked by naltrindole, a δ antagonist, but not by cyprodime, a μ antagonist, of by (±)-U50,488, a κ agonist. Thus, [11C]MeNTI selectively labels central δ opioid receptors in vivo in mouse, and shows promise for positron emission tomography studies of δ sites in human brain.

Original languageEnglish (US)
Pages (from-to)459-460
Number of pages2
JournalEuropean Journal of Pharmacology
Volume216
Issue number3
DOIs
StatePublished - Jun 17 1992

Keywords

  • Naltrindole
  • Opioid receptors
  • PET (positron emmission tomography)
  • δ

ASJC Scopus subject areas

  • Pharmacology

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