In vivo Activity of Colloidal Hamycin, an Antifungal Antibiotic

J. E. Bennett; T. W. Williams; W. Piggott; C. W. Emmons

doi:10.3181/00379727-117-29525

In vivo Activity of Colloidal Hamycin, an Antifungal Antibiotic

J. E. Bennett, T. W. Williams, W. Piggott, C. W. Emmons

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A colloidal dispersion of hamy-cin was prepared, bioassayed, and given par-enterally to mice infected with Cryptococcus neoformans or Histoplasma capsulatum. Either infection was sterilized in many mice when doses of hamycin approached toxic levels. Colloidal hamycin given orally controlled cryptococcosis in mice and caused no obvious toxicity. The rabbit was more sensitive than the mouse to the lethal effects of colloidal hamycin injected intravenously. The cause of death in the rabbit was cardiotoxic-ity. Hamycin used in these experiments was obtained from Hindustan Antibiotics, Ltd., through the courtesy of M. J. Thirumalachar.

Original language	English (US)
Pages (from-to)	166-170
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	117
Issue number	1
DOIs	https://doi.org/10.3181/00379727-117-29525
State	Published - Oct 1964

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "In vivo Activity of Colloidal Hamycin, an Antifungal Antibiotic",

abstract = "A colloidal dispersion of hamy-cin was prepared, bioassayed, and given par-enterally to mice infected with Cryptococcus neoformans or Histoplasma capsulatum. Either infection was sterilized in many mice when doses of hamycin approached toxic levels. Colloidal hamycin given orally controlled cryptococcosis in mice and caused no obvious toxicity. The rabbit was more sensitive than the mouse to the lethal effects of colloidal hamycin injected intravenously. The cause of death in the rabbit was cardiotoxic-ity. Hamycin used in these experiments was obtained from Hindustan Antibiotics, Ltd., through the courtesy of M. J. Thirumalachar.",

author = "Bennett, {J. E.} and Williams, {T. W.} and W. Piggott and Emmons, {C. W.}",

year = "1964",

month = oct,

doi = "10.3181/00379727-117-29525",

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T1 - In vivo Activity of Colloidal Hamycin, an Antifungal Antibiotic

AU - Bennett, J. E.

AU - Williams, T. W.

AU - Piggott, W.

AU - Emmons, C. W.

PY - 1964/10

Y1 - 1964/10

N2 - A colloidal dispersion of hamy-cin was prepared, bioassayed, and given par-enterally to mice infected with Cryptococcus neoformans or Histoplasma capsulatum. Either infection was sterilized in many mice when doses of hamycin approached toxic levels. Colloidal hamycin given orally controlled cryptococcosis in mice and caused no obvious toxicity. The rabbit was more sensitive than the mouse to the lethal effects of colloidal hamycin injected intravenously. The cause of death in the rabbit was cardiotoxic-ity. Hamycin used in these experiments was obtained from Hindustan Antibiotics, Ltd., through the courtesy of M. J. Thirumalachar.

AB - A colloidal dispersion of hamy-cin was prepared, bioassayed, and given par-enterally to mice infected with Cryptococcus neoformans or Histoplasma capsulatum. Either infection was sterilized in many mice when doses of hamycin approached toxic levels. Colloidal hamycin given orally controlled cryptococcosis in mice and caused no obvious toxicity. The rabbit was more sensitive than the mouse to the lethal effects of colloidal hamycin injected intravenously. The cause of death in the rabbit was cardiotoxic-ity. Hamycin used in these experiments was obtained from Hindustan Antibiotics, Ltd., through the courtesy of M. J. Thirumalachar.

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In vivo Activity of Colloidal Hamycin, an Antifungal Antibiotic

Abstract

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