In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement

A. Bradu; R. Sablong; C. Julien; I. Troprès; J. F. Payen; Jacques Derouard

doi:10.1117/12.447121

In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement

A. Bradu, R. Sablong, C. Julien, I. Troprès, J. F. Payen, Jacques Derouard

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Broad band light absorption spectroscopy in the visible range (520-590 nm) has been carried out using implanted small optical fibers to probe the hemodynamics of deep tissues (striatum) in rat brain subjected to hypoxia, we observe a decrease of the cerebral blood oxygenation by a factor of up to two, while the cerebral blood volume (CBV) does not seem to increase significantly. However, nuclear magnetic resonance measurements of CBV in the same conditions using a magnetic contrast agent show that CBV increases by about 50%. This shows that absorption spectroscopy in the visible range strongly underestimates the CBV, probably due to the confinement of blood in vessels. This effect is confirmed by absorption spectroscopy measurements performed in phantoms with similar geometry.

Original language	English (US)
Pages (from-to)	85-90
Number of pages	6
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4432
DOIs	https://doi.org/10.1117/12.447121
State	Published - 2001
Externally published	Yes

Keywords

Blood/tissue constituent monitoring
Medical Optics and Biotechnology
Spectroscopy
Tissue diagnostics

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.447121

Cite this

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title = "In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement",

abstract = "Broad band light absorption spectroscopy in the visible range (520-590 nm) has been carried out using implanted small optical fibers to probe the hemodynamics of deep tissues (striatum) in rat brain subjected to hypoxia, we observe a decrease of the cerebral blood oxygenation by a factor of up to two, while the cerebral blood volume (CBV) does not seem to increase significantly. However, nuclear magnetic resonance measurements of CBV in the same conditions using a magnetic contrast agent show that CBV increases by about 50%. This shows that absorption spectroscopy in the visible range strongly underestimates the CBV, probably due to the confinement of blood in vessels. This effect is confirmed by absorption spectroscopy measurements performed in phantoms with similar geometry.",

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T1 - In vivo absorption spectroscopy in brain using small optical fiber probes

T2 - Effect of blood confinement

AU - Bradu, A.

AU - Sablong, R.

AU - Julien, C.

AU - Troprès, I.

AU - Payen, J. F.

AU - Derouard, Jacques

PY - 2001

Y1 - 2001

N2 - Broad band light absorption spectroscopy in the visible range (520-590 nm) has been carried out using implanted small optical fibers to probe the hemodynamics of deep tissues (striatum) in rat brain subjected to hypoxia, we observe a decrease of the cerebral blood oxygenation by a factor of up to two, while the cerebral blood volume (CBV) does not seem to increase significantly. However, nuclear magnetic resonance measurements of CBV in the same conditions using a magnetic contrast agent show that CBV increases by about 50%. This shows that absorption spectroscopy in the visible range strongly underestimates the CBV, probably due to the confinement of blood in vessels. This effect is confirmed by absorption spectroscopy measurements performed in phantoms with similar geometry.

AB - Broad band light absorption spectroscopy in the visible range (520-590 nm) has been carried out using implanted small optical fibers to probe the hemodynamics of deep tissues (striatum) in rat brain subjected to hypoxia, we observe a decrease of the cerebral blood oxygenation by a factor of up to two, while the cerebral blood volume (CBV) does not seem to increase significantly. However, nuclear magnetic resonance measurements of CBV in the same conditions using a magnetic contrast agent show that CBV increases by about 50%. This shows that absorption spectroscopy in the visible range strongly underestimates the CBV, probably due to the confinement of blood in vessels. This effect is confirmed by absorption spectroscopy measurements performed in phantoms with similar geometry.

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In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement

Abstract

Keywords

ASJC Scopus subject areas

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