In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement

A. Bradu, R. Sablong, C. Julien, I. Troprès, J. F. Payen, Jacques Derouard

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Broad band light absorption spectroscopy in the visible range (520-590 nm) has been carried out using implanted small optical fibers to probe the hemodynamics of deep tissues (striatum) in rat brain subjected to hypoxia, we observe a decrease of the cerebral blood oxygenation by a factor of up to two, while the cerebral blood volume (CBV) does not seem to increase significantly. However, nuclear magnetic resonance measurements of CBV in the same conditions using a magnetic contrast agent show that CBV increases by about 50%. This shows that absorption spectroscopy in the visible range strongly underestimates the CBV, probably due to the confinement of blood in vessels. This effect is confirmed by absorption spectroscopy measurements performed in phantoms with similar geometry.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsT.G. Papazoglou, G.A. Wagnieres
Pages85-90
Number of pages6
Volume4432
DOIs
StatePublished - 2001
Externally publishedYes
EventDiagnostic Optical Spectroscopy in Biomedicine - Munich, Germany
Duration: Jun 19 2001Jun 21 2001

Other

OtherDiagnostic Optical Spectroscopy in Biomedicine
CountryGermany
CityMunich
Period6/19/016/21/01

Fingerprint

blood volume
Absorption spectroscopy
blood
brain
Optical fibers
Brain
absorption spectroscopy
Blood
optical fibers
probes
hemodynamics
oxygenation
hypoxia
electromagnetic absorption
Magnetic resonance measurement
rats
vessels
Oxygenation
Hemodynamics
broadband

Keywords

  • Blood/tissue constituent monitoring
  • Medical Optics and Biotechnology
  • Spectroscopy
  • Tissue diagnostics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Bradu, A., Sablong, R., Julien, C., Troprès, I., Payen, J. F., & Derouard, J. (2001). In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement. In T. G. Papazoglou, & G. A. Wagnieres (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4432, pp. 85-90) https://doi.org/10.1117/12.447121

In vivo absorption spectroscopy in brain using small optical fiber probes : Effect of blood confinement. / Bradu, A.; Sablong, R.; Julien, C.; Troprès, I.; Payen, J. F.; Derouard, Jacques.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / T.G. Papazoglou; G.A. Wagnieres. Vol. 4432 2001. p. 85-90.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bradu, A, Sablong, R, Julien, C, Troprès, I, Payen, JF & Derouard, J 2001, In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement. in TG Papazoglou & GA Wagnieres (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4432, pp. 85-90, Diagnostic Optical Spectroscopy in Biomedicine, Munich, Germany, 6/19/01. https://doi.org/10.1117/12.447121
Bradu A, Sablong R, Julien C, Troprès I, Payen JF, Derouard J. In vivo absorption spectroscopy in brain using small optical fiber probes: Effect of blood confinement. In Papazoglou TG, Wagnieres GA, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4432. 2001. p. 85-90 https://doi.org/10.1117/12.447121
Bradu, A. ; Sablong, R. ; Julien, C. ; Troprès, I. ; Payen, J. F. ; Derouard, Jacques. / In vivo absorption spectroscopy in brain using small optical fiber probes : Effect of blood confinement. Proceedings of SPIE - The International Society for Optical Engineering. editor / T.G. Papazoglou ; G.A. Wagnieres. Vol. 4432 2001. pp. 85-90
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