Abstract
T lymphocytes from immune mice can adoptively transfer protection against infection with the extracellular Gram-negative bacterium Pseudomonas aeruginosa to nonimmune recipients, and in vitro, immune T cells are able to kill these bacteria. Earlier studies indicated that this killing is mediated by a bactericidal lymphokine. Those studies also showed that macrophages enhance this in vitro T cell killing but do not directly participate in the bacterial killing, nor do macrophages function to present antigen to T cells. The current studies demonstrate that the ability of macrophages to enhance T cell killing can be replaced by macrophage culture supernatants or by purified recombinant interleukin 1 (IL 1). In addition, the macrophage supernatant-induced enhancement can also be blocked by antibody to purified IL 1. These studies also demonstrate that the T cell subset that serves as the final effector cell in the killing process is the Lyt-1-,2,3+,I-J+ phenotype.
Original language | English (US) |
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Pages (from-to) | 4112-4117 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 134 |
Issue number | 6 |
State | Published - 1985 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology