In vitro t cell function, delayed-type hypersensitivity skin testing, and cd4+ t cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency Virus

Matthew J. Dolan, Mario Clerici, Stephen P. Blatt, Craig W. Hendrix, Gregory P. Melcher, R. Neal Boswell, Theodore M. Freeman, William Ward, Rex Hensley, Gene M. Shearer

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P <.001) and time for progression to AIDS (P =.014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P <.001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P =.008), the absolute number of CD4+ T cells (P =.001), the percentage of CD4+CD29+ cells (P =.06), and the number of reactive skin tests (P <.001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4+ cell count.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalJournal of Infectious Diseases
Volume172
Issue number1
DOIs
StatePublished - Jul 1995

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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