In vitro synthesis of Fœtal and adult hæmoglobin by fœtal hæmatopoietic tissues

E. Donnall Thomas, Harry L. Lochte, William B. Greenough, Marion Wales

Research output: Contribution to journalLetter

Abstract

THE demonstration of a biochemical distinction between adult and fœtal forms of hæmoglobin (hæmoglobins A and F) has stimulated interest in their physiology and biochemistry1. Little is known about the site of origin or conditions governing the production of these two hæmoglobins. It has been postulated that hæmoglobin A is synthesized in the bone marrow and that hæmoglobin F is produced principally in the liver and spleen2,3. This theory corresponds well with the known sites of red cell production in the fœtus and in the adult2. As a corollary, it has been proposed that hæmoglobin A and hæmoglobin F occur in separate red cells2,4. Anoxia has been thought to increase the production of hæmoglobin F4. This report presents a study of the synthesis of hæmoglobins A and F by hæmatopoietic tissue from two white human fœtuses aged 17 and 9 weeks.

Original languageEnglish (US)
Pages (from-to)396-397
Number of pages2
JournalNature
Volume185
Issue number4710
DOIs
StatePublished - Dec 1 1960
Externally publishedYes

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