TY - JOUR
T1 - In vitro susceptibilities of isolates of Haemophilus ducreyi from Thailand and the United States to currently recommended and newer agents for treatment of chancroid
AU - Knapp, J. S.
AU - Back, A. F.
AU - Babst, A. F.
AU - Taylor, D.
AU - Rice, R. J.
PY - 1993
Y1 - 1993
N2 - We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isolates were susceptible to ≤0.25 μg of ceftriaxone per ml, ≤0.5 μg of cefixime per ml, ≤0.125 μg of ciprofloxacin per ml, and ≤0.06 μg of ofloxacin per ml. Erythromycin was active against all isolates (MIC for 90% of isolates tested, 0.25 μg/ml), as was azithromycin (MIC, ≤0.06 μg/ml). In contrast, all but one isolate were resistant to ≥8.0 μg of tetracycline per ml, 11.1% of the isolates were resistant to ≥8.0 μg of amoxicillin-clavulanic acid per ml, and 40.9% of the isolates were resistant to trimethoprim-sulfamethoxazole (MIC, ≥4/76 μg/ml).
AB - We determined the in vitro susceptibilities of 54 isolates of Haemophilus ducreyi from Thailand (29 isolates) and San Francisco (25 isolates) to penicillin G, tetracycline, amoxicillin-clavulanic acid, ceftriaxone, cefixime, erythromycin, azithromycin, ciprofloxacin, ofloxacin, and trimethoprim-sulfamethoxazole. Isolates were susceptible to ≤0.25 μg of ceftriaxone per ml, ≤0.5 μg of cefixime per ml, ≤0.125 μg of ciprofloxacin per ml, and ≤0.06 μg of ofloxacin per ml. Erythromycin was active against all isolates (MIC for 90% of isolates tested, 0.25 μg/ml), as was azithromycin (MIC, ≤0.06 μg/ml). In contrast, all but one isolate were resistant to ≥8.0 μg of tetracycline per ml, 11.1% of the isolates were resistant to ≥8.0 μg of amoxicillin-clavulanic acid per ml, and 40.9% of the isolates were resistant to trimethoprim-sulfamethoxazole (MIC, ≥4/76 μg/ml).
UR - http://www.scopus.com/inward/record.url?scp=0027300879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027300879&partnerID=8YFLogxK
U2 - 10.1128/AAC.37.7.1552
DO - 10.1128/AAC.37.7.1552
M3 - Comment/debate
C2 - 8363390
AN - SCOPUS:0027300879
VL - 37
SP - 1552
EP - 1555
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 7
ER -